| Title |
Monosomy 13 in metaphase spreads is a predictor of poor long-term outcome after bortezomib plus dexamethasone treatment for relapsed/refractory multiple myeloma
|
|---|---|
| Published in |
International Journal of Hematology, March 2012
|
| DOI | 10.1007/s12185-012-1035-8 |
| Pubmed ID | |
| Authors |
Miki Kiyota, Tsutomu Kobayashi, Shinichi Fuchida, Mio Yamamoto-Sugitani, Muneo Ohshiro, Yuji Shimura, Shinsuke Mizutani, Hisao Nagoshi, Nana Sasaki, Ryuko Nakayama, Yoshiaki Chinen, Natsumi Sakamoto, Hitoji Uchiyama, Yosuke Matsumoto, Shigeo Horiike, Chihiro Shimazaki, Junya Kuroda, Masafumi Taniwaki |
| Abstract |
We retrospectively investigated the prognostic impact of high-risk cytogenetic abnormalities (CAs) on the outcome of treatment with bortezomib plus dexamethasone (BD) in 43 relapsed/refractory (Rel/Ref) multiple myeloma patients. Fluorescence in situ hybridization (FISH) analysis identified del(13q) in 25 patients, t(4;14) in 14, t(14;16) in 4, 1q21 abnormality in 12 and del(17p) in 2, while G-banding also detected chromosome 13 monosomy (-13) in metaphase spreads from 7 patients. Eighteen of 25 patients with FISH-detected chromosome 13 abnormalities also exhibited other abnormalities. Median observation period was 510 days, and median overall survival (OS) and progression-free survival (PFS) were 912 days and 162 days, respectively. Detection of del(13q), t(4;14), t(14;16) or 1q21 abnormalities by FISH and co-occurrence of chromosome 13 abnormality with other abnormalities were not associated with poorer outcomes. In contrast, detection of -13 by G-banding in metaphase spreads showed significant association with shorter OS, although the overall response rate and PFS were not inferior to those for patients without -13 detected by G-banding. BD therapy may be a potent weapon for overcoming most classical high-risk CAs, while the detection of -13 in metaphase spreads may serve as a predictor of highly progressive disease, even when treated with BD. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Korea, Republic of | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Croatia | 1 | 4% |
| United States | 1 | 4% |
| Unknown | 21 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 43% |
| Student > Ph. D. Student | 3 | 13% |
| Other | 2 | 9% |
| Lecturer | 1 | 4% |
| Student > Master | 1 | 4% |
| Other | 3 | 13% |
| Unknown | 3 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 39% |
| Agricultural and Biological Sciences | 4 | 17% |
| Psychology | 3 | 13% |
| Nursing and Health Professions | 1 | 4% |
| Environmental Science | 1 | 4% |
| Other | 2 | 9% |
| Unknown | 3 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2012.
All research outputs
#14,725,323
of 22,663,969 outputs
Outputs from International Journal of Hematology
#650
of 1,384 outputs
Outputs of similar age
#109,517
of 176,076 outputs
Outputs of similar age from International Journal of Hematology
#7
of 19 outputs
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