Title |
Development of Leiomyosarcoma in a Patient Treated with Azathioprine.
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Published in |
South Dakota Medicine, May 2019
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Pubmed ID | |
Authors |
Mohamed Abdallah, Mohamed Saleh, Hesham Elgouhari, Mark K Huntington |
Abstract |
Cirrhosis resulting from autoimmune hepatitis is associated with an increased risk of hepatocellular carcinoma. A common treatment for autoimmune hepatitis, azathioprine, is also associated with the development of many other cancers, predominantly lymphomas. The strongest association is seen for post-transplant lymphoma and hepatosplenic T-cell lymphoma in Crohn's disease and ulcerative colitis patients; there is also an association with a variety of cutaneous malignancies. A relationship between azathioprine and sarcoma has not been demonstrated, though there have been sporadic case reports. We report here the development of leiomyosarcoma in a patient who was treated with azathioprine for autoimmune hepatitis without cirrhosis. |
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Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 3 | 27% |
Student > Master | 2 | 18% |
Other | 1 | 9% |
Student > Ph. D. Student | 1 | 9% |
Lecturer > Senior Lecturer | 1 | 9% |
Other | 0 | 0% |
Unknown | 3 | 27% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 36% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 18% |
Computer Science | 1 | 9% |
Biochemistry, Genetics and Molecular Biology | 1 | 9% |
Unknown | 3 | 27% |