Title |
Consensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias
|
---|---|
Published in |
The Cerebellum, March 2015
|
DOI | 10.1007/s12311-015-0664-x |
Pubmed ID | |
Authors |
Hiroshi Mitoma, Keya Adhikari, Daniel Aeschlimann, Partha Chattopadhyay, Marios Hadjivassiliou, Christiane S. Hampe, Jérôme Honnorat, Bastien Joubert, Shinji Kakei, Jongho Lee, Mario Manto, Akiko Matsunaga, Hidehiro Mizusawa, Kazunori Nanri, Priya Shanmugarajah, Makoto Yoneda, Nobuhiro Yuki |
Abstract |
In the last few years, a lot of publications suggested that disabling cerebellar ataxias may develop through immune-mediated mechanisms. In this consensus paper, we discuss the clinical features of the main described immune-mediated cerebellar ataxias and address their presumed pathogenesis. Immune-mediated cerebellar ataxias include cerebellar ataxia associated with anti-GAD antibodies, the cerebellar type of Hashimoto's encephalopathy, primary autoimmune cerebellar ataxia, gluten ataxia, Miller Fisher syndrome, ataxia associated with systemic lupus erythematosus, and paraneoplastic cerebellar degeneration. Humoral mechanisms, cell-mediated immunity, inflammation, and vascular injuries contribute to the cerebellar deficits in immune-mediated cerebellar ataxias. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Italy | 1 | <1% |
South Africa | 1 | <1% |
Unknown | 166 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 25 | 15% |
Researcher | 21 | 12% |
Student > Ph. D. Student | 17 | 10% |
Student > Master | 15 | 9% |
Student > Doctoral Student | 15 | 9% |
Other | 43 | 25% |
Unknown | 33 | 20% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 64 | 38% |
Neuroscience | 23 | 14% |
Nursing and Health Professions | 8 | 5% |
Agricultural and Biological Sciences | 8 | 5% |
Biochemistry, Genetics and Molecular Biology | 6 | 4% |
Other | 15 | 9% |
Unknown | 45 | 27% |