↓ Skip to main content

Autoantibodies to neuronal antigens in children with focal epilepsy and no prima facie signs of encephalitis

Overview of attention for article published in European Journal of Paediatric Neurology, March 2016
Altmetric Badge

Mentioned by

twitter
1 X user

Citations

dimensions_citation
21 Dimensions

Readers on

mendeley
29 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Autoantibodies to neuronal antigens in children with focal epilepsy and no prima facie signs of encephalitis
Published in
European Journal of Paediatric Neurology, March 2016
DOI 10.1016/j.ejpn.2016.03.005
Pubmed ID
Authors

Peter Borusiak, Ulrich Bettendorf, Gert Wiegand, Thomas Bast, Gerhard Kluger, Heike Philippi, Dieter Münstermann, Christian G. Bien

Abstract

There is increasing awareness of neuronal autoantibodies and their impact on the pathogenesis of epilepsy. We investigated children with focal epilepsy in order to provide an estimate of autoantibody frequency within a pediatric population without prima facie evidence of encephalitis using a broad panel of autoantibodies. This was done to assess the specificity of antibodies and to see whether antibodies might be of modifying influence on the course of focal epilepsies. We searched for autoantibodies in 124 patients with focal epilepsy (1-18 years; mean 10; 6 years). Sera were tested using a broad panel of surface and intracellular antigens. We found autoantibodies in 5/124 patients (4%): high-positive GAD65 antibodies (n = 1), low-positive GAD65 antibodies (N = 1), VGKC complex antibodies not reactive with LGI1 or CASPR2 (n = 3). We did not find any distinctive features distinguishing antibody positive patients from those without antibodies. The antibodies found in this cohort are probably neither disease-specific nor pathogenic. This has been suggested before for these antigenic targets. Moreover, they do not seem to modify disease severity in the antibody-positive epilepsy patients.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 28%
Student > Bachelor 4 14%
Student > Doctoral Student 3 10%
Student > Master 3 10%
Other 2 7%
Other 4 14%
Unknown 5 17%
Readers by discipline Count As %
Medicine and Dentistry 14 48%
Neuroscience 7 24%
Biochemistry, Genetics and Molecular Biology 1 3%
Nursing and Health Professions 1 3%
Unknown 6 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2016.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from European Journal of Paediatric Neurology
#917
of 1,112 outputs
Outputs of similar age
#272,291
of 315,360 outputs
Outputs of similar age from European Journal of Paediatric Neurology
#34
of 43 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,112 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,360 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.