| Title |
The gateway to transcription: identifying, characterizing and understanding promoters in the eukaryotic genome
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, December 2006
|
| DOI | 10.1007/s00018-006-6295-0 |
| Pubmed ID | |
| Authors |
N. D. Heintzman, B. Ren |
| Abstract |
Eukaryotic transcriptional regulation requires the integration of complex signals by the transcriptional promoter. Distinct sequence elements, characteristic chromatin modifications and coordinated protein-DNA interactions at these sequences constitute a transcriptional regulatory code that remains poorly understood today. Here, we review recent experimental and computational advances that have enabled the identification and analysis of transcriptional promoters on an unprecedented scale, laying a foundation for systematic determination of the transcriptional regulatory networks in eukaryotic cells. The knowledge gained from these large-scale investigations has challenged some conventional concepts of promoter structure and function, and provided valuable insights into the complex gene regulatory mechanisms in a variety of organisms. |
Mendeley readers
The data shown below were compiled from readership statistics for 180 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| United Kingdom | 3 | 2% |
| Germany | 2 | 1% |
| Brazil | 2 | 1% |
| Sweden | 1 | <1% |
| Israel | 1 | <1% |
| India | 1 | <1% |
| France | 1 | <1% |
| New Zealand | 1 | <1% |
| Other | 3 | 2% |
| Unknown | 161 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 53 | 29% |
| Researcher | 39 | 22% |
| Student > Master | 15 | 8% |
| Professor | 15 | 8% |
| Student > Doctoral Student | 12 | 7% |
| Other | 30 | 17% |
| Unknown | 16 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 92 | 51% |
| Biochemistry, Genetics and Molecular Biology | 47 | 26% |
| Medicine and Dentistry | 5 | 3% |
| Computer Science | 5 | 3% |
| Immunology and Microbiology | 2 | 1% |
| Other | 9 | 5% |
| Unknown | 20 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2012.
All research outputs
#16,031,680
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#3,071
of 4,151 outputs
Outputs of similar age
#136,432
of 160,011 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#35
of 36 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
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We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.