| Title |
Mapping Loci for Fox Domestication: Deconstruction/Reconstruction of a Behavioral Phenotype
|
|---|---|
| Published in |
Behavior Genetics, December 2010
|
| DOI | 10.1007/s10519-010-9418-1 |
| Pubmed ID | |
| Authors |
Anna V. Kukekova, Lyudmila N. Trut, Kevin Chase, Anastasiya V. Kharlamova, Jennifer L. Johnson, Svetlana V. Temnykh, Irina N. Oskina, Rimma G. Gulevich, Anastasiya V. Vladimirova, Simon Klebanov, Darya V. Shepeleva, Svetlana G. Shikhevich, Gregory M. Acland, Karl G. Lark |
| Abstract |
During the second part of the twentieth century, Belyaev selected tame and aggressive foxes (Vulpes vulpes), in an effort known as the "farm-fox experiment", to recapitulate the process of animal domestication. Using these tame and aggressive foxes as founders of segregant backcross and intercross populations we have employed interval mapping to identify a locus for tame behavior on fox chromosome VVU12. This locus is orthologous to, and therefore validates, a genomic region recently implicated in canine domestication. The tame versus aggressive behavioral phenotype was characterized as the first principal component (PC) of a PC matrix made up of many distinct behavioral traits (e.g. wags tail; comes to the front of the cage; allows head to be touched; holds observer's hand with its mouth; etc.). Mean values of this PC for F1, backcross and intercross populations defined a linear gradient of heritable behavior ranging from tame to aggressive. The second PC did not follow such a gradient, but also mapped to VVU12, and distinguished between active and passive behaviors. These data suggest that (1) there are at least two VVU12 loci associated with behavior; (2) expression of these loci is dependent on interactions with other parts of the genome (the genome context) and therefore varies from one crossbred population to another depending on the individual parents that participated in the cross. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 203 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Brazil | 2 | <1% |
| Portugal | 1 | <1% |
| Colombia | 1 | <1% |
| Turkey | 1 | <1% |
| India | 1 | <1% |
| United Arab Emirates | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| United Kingdom | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 190 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 36 | 18% |
| Student > Ph. D. Student | 34 | 17% |
| Student > Master | 31 | 15% |
| Student > Bachelor | 28 | 14% |
| Other | 17 | 8% |
| Other | 32 | 16% |
| Unknown | 25 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 107 | 53% |
| Environmental Science | 23 | 11% |
| Biochemistry, Genetics and Molecular Biology | 12 | 6% |
| Veterinary Science and Veterinary Medicine | 7 | 3% |
| Social Sciences | 7 | 3% |
| Other | 17 | 8% |
| Unknown | 30 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2022.
All research outputs
#1,172,696
of 23,414,653 outputs
Outputs from Behavior Genetics
#56
of 922 outputs
Outputs of similar age
#6,002
of 183,509 outputs
Outputs of similar age from Behavior Genetics
#2
of 12 outputs
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