| Title |
Understanding the CREB1-miRNA feedback loop in human malignancies
|
|---|---|
| Published in |
Tumor Biology, April 2016
|
| DOI | 10.1007/s13277-016-5050-x |
| Pubmed ID | |
| Authors |
Ya-Wen Wang, Xu Chen, Rong Ma, Peng Gao |
| Abstract |
cAMP response element binding protein 1 (CREB1, CREB) is a key transcription factor that mediates transcriptional responses to a variety of growth factors and stress signals. CREB1 has been shown to play a critical role in development and progression of tumors. MicroRNAs (miRNAs) are a class of non-coding RNAs. They post-transcriptionally regulate gene expression through pairing with the 3'-UTR of their target mRNAs and thus regulate initiation and progression of various types of human cancers. Recent studies have demonstrated that a number of miRNAs can be transcriptionally regulated by CREB1. Interestingly, CREB1 expression can also be modulated by miRNAs, thus forming a feedback loop. This review outlines the functional roles of CREB1, miRNA, and their interactions in human malignancies. This will help to define a relationship between CREB1 and miRNA in human cancer and develop novel therapeutic strategies. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 14% |
| Student > Bachelor | 4 | 14% |
| Student > Master | 3 | 11% |
| Researcher | 2 | 7% |
| Student > Postgraduate | 2 | 7% |
| Other | 5 | 18% |
| Unknown | 8 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 6 | 21% |
| Medicine and Dentistry | 6 | 21% |
| Biochemistry, Genetics and Molecular Biology | 5 | 18% |
| Sports and Recreations | 1 | 4% |
| Linguistics | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 9 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2016.
All research outputs
#19,054,237
of 23,613,071 outputs
Outputs from Tumor Biology
#1,389
of 2,614 outputs
Outputs of similar age
#222,718
of 302,284 outputs
Outputs of similar age from Tumor Biology
#25
of 44 outputs
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