| Title |
Methylphenidate Exposure Induces Dopamine Neuron Loss and Activation of Microglia in the Basal Ganglia of Mice
|
|---|---|
| Published in |
PLOS ONE, March 2012
|
| DOI | 10.1371/journal.pone.0033693 |
| Pubmed ID | |
| Authors |
Shankar Sadasivan, Brooks B. Pond, Amar K. Pani, Chunxu Qu, Yun Jiao, Richard J. Smeyne |
| Abstract |
Methylphenidate (MPH) is a psychostimulant that exerts its pharmacological effects via preferential blockade of the dopamine transporter (DAT) and the norepinephrine transporter (NET), resulting in increased monoamine levels in the synapse. Clinically, methylphenidate is prescribed for the symptomatic treatment of ADHD and narcolepsy; although lately, there has been an increased incidence of its use in individuals not meeting the criteria for these disorders. MPH has also been misused as a "cognitive enhancer" and as an alternative to other psychostimulants. Here, we investigate whether chronic or acute administration of MPH in mice at either 1 mg/kg or 10 mg/kg, affects cell number and gene expression in the basal ganglia. |
X Demographics
The data shown below were collected from the profiles of 66 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 16 | 24% |
| United Kingdom | 2 | 3% |
| Comoros | 1 | 2% |
| Korea, Republic of | 1 | 2% |
| Serbia | 1 | 2% |
| Yemen | 1 | 2% |
| Australia | 1 | 2% |
| France | 1 | 2% |
| Indonesia | 1 | 2% |
| Other | 4 | 6% |
| Unknown | 37 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 59 | 89% |
| Practitioners (doctors, other healthcare professionals) | 4 | 6% |
| Scientists | 2 | 3% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 106 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 19% |
| Student > Bachelor | 19 | 18% |
| Student > Ph. D. Student | 15 | 14% |
| Student > Doctoral Student | 8 | 7% |
| Student > Master | 8 | 7% |
| Other | 14 | 13% |
| Unknown | 23 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 15% |
| Psychology | 14 | 13% |
| Medicine and Dentistry | 13 | 12% |
| Biochemistry, Genetics and Molecular Biology | 9 | 8% |
| Neuroscience | 9 | 8% |
| Other | 19 | 18% |
| Unknown | 28 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 103. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2023.
All research outputs
#413,268
of 25,654,806 outputs
Outputs from PLOS ONE
#5,807
of 223,967 outputs
Outputs of similar age
#1,791
of 173,263 outputs
Outputs of similar age from PLOS ONE
#74
of 3,733 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 223,967 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 173,263 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 3,733 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.