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A Novel IL-10–Independent Regulatory Role for B Cells in Suppressing Autoimmunity by Maintenance of Regulatory T Cells via GITR Ligand

Overview of attention for article published in The Journal of Immunology, April 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

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2 patents
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1 research highlight platform

Citations

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224 Dimensions

Readers on

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147 Mendeley
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Title
A Novel IL-10–Independent Regulatory Role for B Cells in Suppressing Autoimmunity by Maintenance of Regulatory T Cells via GITR Ligand
Published in
The Journal of Immunology, April 2012
DOI 10.4049/jimmunol.1103354
Pubmed ID
Authors

Avijit Ray, Sreemanti Basu, Calvin B. Williams, Nita H. Salzman, Bonnie N. Dittel

Abstract

B cells are important for the regulation of autoimmune responses. In experimental autoimmune encephalomyelitis (EAE), B cells are required for spontaneous recovery in acute models. Production of IL-10 by regulatory B cells has been shown to modulate the severity EAE and other autoimmune diseases. Previously, we suggested that B cells regulated the number of CD4(+)Foxp3(+) T regulatory cells (Treg) in the CNS during EAE. Because Treg suppress autoimmune responses, we asked whether B cells control autoimmunity by maintenance of Treg numbers. B cell deficiency achieved either genetically (μMT) or by depletion with anti-CD20 resulted in a significant reduction in the number of peripheral but not thymic Treg. Adoptive transfer of WT B cells into μMT mice restored both Treg numbers and recovery from EAE. When we investigated the mechanism whereby B cells induce the proliferation of Treg and EAE recovery, we found that glucocorticoid-induced TNF ligand, but not IL-10, expression by B cells was required. Of clinical significance is the finding that anti-CD20 depletion of B cells accelerated spontaneous EAE and colitis. Our results demonstrate that B cells play a major role in immune tolerance required for the prevention of autoimmunity by maintenance of Treg via their expression of glucocorticoid-induced TNFR ligand.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 <1%
Ireland 1 <1%
Singapore 1 <1%
Switzerland 1 <1%
Unknown 143 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 36 24%
Student > Ph. D. Student 26 18%
Student > Bachelor 14 10%
Student > Master 11 7%
Professor 10 7%
Other 30 20%
Unknown 20 14%
Readers by discipline Count As %
Immunology and Microbiology 31 21%
Agricultural and Biological Sciences 31 21%
Medicine and Dentistry 30 20%
Biochemistry, Genetics and Molecular Biology 13 9%
Psychology 3 2%
Other 12 8%
Unknown 27 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 February 2023.
All research outputs
#4,599,559
of 23,577,761 outputs
Outputs from The Journal of Immunology
#3,747
of 27,978 outputs
Outputs of similar age
#28,210
of 162,469 outputs
Outputs of similar age from The Journal of Immunology
#23
of 195 outputs
Altmetric has tracked 23,577,761 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 27,978 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 162,469 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 195 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.