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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer
|
|---|---|
| Published in |
Scientific Reports, April 2016
|
| DOI | 10.1038/srep23179 |
| Pubmed ID | |
| Authors |
Hitesh Kulhari, Deep Pooja, Shweta Shrivastava, Madhusudana Kuncha, V. G. M. Naidu, Vipul Bansal, Ramakrishna Sistla, David J. Adams |
| Abstract |
Approximately 20% of breast cancer cases are human epidermal growth factor receptor 2 (HER2)-positive. This type of breast cancer is more aggressive and tends to reoccur more often than HER2-negative breast cancer. In this study, we synthesized trastuzumab (TZ)-grafted dendrimers to improve delivery of docetaxel (DTX) to HER2-positive breast cancer cells. Bioconjugation of TZ on the surface of dendrimers was performed using a heterocrosslinker, MAL-PEG-NHS. For imaging of cancer cells, dendrimers were also conjugated to fluorescein isothiocyanate. Comparative in vitro studies revealed that these targeted dendrimers were more selective, and had higher antiproliferation activity, towards HER2-positive MDA-MB-453 human breast cancer cells than HER2-negative MDA-MB-231 human breast cancer cells. When compared with unconjugated dendrimers, TZ-conjugated dendrimers also displayed higher cellular internalization and induction of apoptosis against MDA-MB-453 cells. Binding of TZ to the dendrimer surface could help site-specific delivery of DTX and reduce systemic toxicity resulting from its lack of specificity. In addition, in vivo studies revealed that the pharmacokinetic profile of DTX was significantly improved by the conjugated nanosystem. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 13% |
| United Kingdom | 2 | 13% |
| Thailand | 1 | 6% |
| France | 1 | 6% |
| Uruguay | 1 | 6% |
| Chile | 1 | 6% |
| Unknown | 8 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 94% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 166 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | <1% |
| Unknown | 165 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 14% |
| Researcher | 21 | 13% |
| Student > Master | 21 | 13% |
| Student > Bachelor | 18 | 11% |
| Student > Doctoral Student | 8 | 5% |
| Other | 23 | 14% |
| Unknown | 52 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 27 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 26 | 16% |
| Medicine and Dentistry | 11 | 7% |
| Biochemistry, Genetics and Molecular Biology | 10 | 6% |
| Agricultural and Biological Sciences | 9 | 5% |
| Other | 29 | 17% |
| Unknown | 54 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2024.
All research outputs
#3,635,328
of 25,759,158 outputs
Outputs from Scientific Reports
#30,751
of 142,850 outputs
Outputs of similar age
#55,473
of 316,457 outputs
Outputs of similar age from Scientific Reports
#741
of 3,151 outputs
Altmetric has tracked 25,759,158 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 142,850 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.8. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,457 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 3,151 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.