Title |
Small molecules, big targets: drug discovery faces the protein–protein interaction challenge
|
---|---|
Published in |
Nature Reviews Drug Discovery, April 2016
|
DOI | 10.1038/nrd.2016.29 |
Pubmed ID | |
Authors |
Duncan E. Scott, Andrew R. Bayly, Chris Abell, John Skidmore |
Abstract |
Protein-protein interactions (PPIs) are of pivotal importance in the regulation of biological systems and are consequently implicated in the development of disease states. Recent work has begun to show that, with the right tools, certain classes of PPI can yield to the efforts of medicinal chemists to develop inhibitors, and the first PPI inhibitors have reached clinical development. In this Review, we describe the research leading to these breakthroughs and highlight the existence of groups of structurally related PPIs within the PPI target class. For each of these groups, we use examples of successful discovery efforts to illustrate the research strategies that have proved most useful. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 15 | 27% |
United Kingdom | 8 | 14% |
Canada | 2 | 4% |
France | 2 | 4% |
Thailand | 1 | 2% |
Australia | 1 | 2% |
Argentina | 1 | 2% |
India | 1 | 2% |
Brazil | 1 | 2% |
Other | 3 | 5% |
Unknown | 21 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 36 | 64% |
Scientists | 19 | 34% |
Practitioners (doctors, other healthcare professionals) | 1 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 8 | <1% |
United Kingdom | 8 | <1% |
Germany | 4 | <1% |
Spain | 3 | <1% |
Japan | 3 | <1% |
Brazil | 2 | <1% |
France | 1 | <1% |
Austria | 1 | <1% |
Italy | 1 | <1% |
Other | 9 | <1% |
Unknown | 1376 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 336 | 24% |
Researcher | 275 | 19% |
Student > Master | 154 | 11% |
Student > Bachelor | 136 | 10% |
Student > Doctoral Student | 51 | 4% |
Other | 190 | 13% |
Unknown | 274 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 399 | 28% |
Biochemistry, Genetics and Molecular Biology | 281 | 20% |
Agricultural and Biological Sciences | 172 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 72 | 5% |
Medicine and Dentistry | 39 | 3% |
Other | 150 | 11% |
Unknown | 303 | 21% |