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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Small molecules, big targets: drug discovery faces the protein–protein interaction challenge
|
|---|---|
| Published in |
Nature Reviews Drug Discovery, April 2016
|
| DOI | 10.1038/nrd.2016.29 |
| Pubmed ID | |
| Authors |
Duncan E. Scott, Andrew R. Bayly, Chris Abell, John Skidmore |
| Abstract |
Protein-protein interactions (PPIs) are of pivotal importance in the regulation of biological systems and are consequently implicated in the development of disease states. Recent work has begun to show that, with the right tools, certain classes of PPI can yield to the efforts of medicinal chemists to develop inhibitors, and the first PPI inhibitors have reached clinical development. In this Review, we describe the research leading to these breakthroughs and highlight the existence of groups of structurally related PPIs within the PPI target class. For each of these groups, we use examples of successful discovery efforts to illustrate the research strategies that have proved most useful. |
X Demographics
The data shown below were collected from the profiles of 56 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 15 | 27% |
| United Kingdom | 8 | 14% |
| Canada | 2 | 4% |
| France | 2 | 4% |
| Thailand | 1 | 2% |
| Australia | 1 | 2% |
| Argentina | 1 | 2% |
| India | 1 | 2% |
| Brazil | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 21 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 36 | 64% |
| Scientists | 19 | 34% |
| Practitioners (doctors, other healthcare professionals) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,414 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | <1% |
| United Kingdom | 8 | <1% |
| Germany | 4 | <1% |
| Spain | 3 | <1% |
| Japan | 3 | <1% |
| Brazil | 2 | <1% |
| France | 1 | <1% |
| Austria | 1 | <1% |
| Italy | 1 | <1% |
| Other | 9 | <1% |
| Unknown | 1374 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 336 | 24% |
| Researcher | 275 | 19% |
| Student > Master | 154 | 11% |
| Student > Bachelor | 136 | 10% |
| Student > Doctoral Student | 51 | 4% |
| Other | 188 | 13% |
| Unknown | 274 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 399 | 28% |
| Biochemistry, Genetics and Molecular Biology | 281 | 20% |
| Agricultural and Biological Sciences | 172 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 72 | 5% |
| Medicine and Dentistry | 39 | 3% |
| Other | 148 | 10% |
| Unknown | 303 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 75. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2024.
All research outputs
#584,253
of 25,732,188 outputs
Outputs from Nature Reviews Drug Discovery
#260
of 3,692 outputs
Outputs of similar age
#10,552
of 317,205 outputs
Outputs of similar age from Nature Reviews Drug Discovery
#2
of 62 outputs
Altmetric has tracked 25,732,188 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,692 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.2. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,205 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.