| Title |
Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics
|
|---|---|
| Published in |
Clinical Pharmacokinetics, September 2015
|
| DOI | 10.1007/s40262-015-0328-5 |
| Pubmed ID | |
| Authors |
Miriam G. Mooij, Anne T. Nies, Catherijne A. J. Knibbe, Elke Schaeffeler, Dick Tibboel, Matthias Schwab, Saskia N. de Wildt |
| Abstract |
Membrane transporters play an essential role in the transport of endogenous and exogenous compounds, and consequently they mediate the uptake, distribution, and excretion of many drugs. The clinical relevance of transporters in drug disposition and their effect in adults have been shown in drug-drug interaction and pharmacogenomic studies. Little is known, however, about the ontogeny of human membrane transporters and their roles in pediatric pharmacotherapy. As they are involved in the transport of endogenous substrates, growth and development may be important determinants of their expression and activity. This review presents an overview of our current knowledge on human membrane transporters in pediatric drug disposition and effect. Existing pharmacokinetic and pharmacogenetic data on membrane substrate drugs frequently used in children are presented and related, where possible, to existing ex vivo data, providing a basis for developmental patterns for individual human membrane transporters. As data for individual transporters are currently still scarce, there is a striking information gap regarding the role of human membrane transporters in drug therapy in children. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Switzerland | 1 | 1% |
| Unknown | 74 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 22% |
| Researcher | 13 | 17% |
| Student > Master | 12 | 16% |
| Student > Bachelor | 7 | 9% |
| Student > Doctoral Student | 5 | 7% |
| Other | 14 | 18% |
| Unknown | 8 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 23 | 30% |
| Medicine and Dentistry | 15 | 20% |
| Biochemistry, Genetics and Molecular Biology | 11 | 14% |
| Agricultural and Biological Sciences | 8 | 11% |
| Engineering | 2 | 3% |
| Other | 5 | 7% |
| Unknown | 12 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2016.
All research outputs
#14,256,395
of 22,860,626 outputs
Outputs from Clinical Pharmacokinetics
#1,127
of 1,481 outputs
Outputs of similar age
#142,250
of 274,906 outputs
Outputs of similar age from Clinical Pharmacokinetics
#10
of 17 outputs
Altmetric has tracked 22,860,626 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,481 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,906 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.