Title |
Coordinated regulation of myeloid cells by tumours
|
---|---|
Published in |
Nature Reviews Immunology, March 2012
|
DOI | 10.1038/nri3175 |
Pubmed ID | |
Authors |
Dmitry I. Gabrilovich, Suzanne Ostrand-Rosenberg, Vincenzo Bronte |
Abstract |
Myeloid cells are the most abundant nucleated haematopoietic cells in the human body and are a collection of distinct cell populations with many diverse functions. The three groups of terminally differentiated myeloid cells - macrophages, dendritic cells and granulocytes - are essential for the normal function of both the innate and adaptive immune systems. Mounting evidence indicates that the tumour microenvironment alters myeloid cells and can convert them into potent immunosuppressive cells. Here, we consider myeloid cells as an intricately connected, complex, single system and we focus on how tumours manipulate the myeloid system to evade the host immune response. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 33% |
United States | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 23 | 1% |
Netherlands | 6 | <1% |
Germany | 5 | <1% |
Sweden | 4 | <1% |
France | 3 | <1% |
Spain | 3 | <1% |
United Kingdom | 3 | <1% |
Belgium | 2 | <1% |
Denmark | 2 | <1% |
Other | 20 | <1% |
Unknown | 2161 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 501 | 22% |
Researcher | 433 | 19% |
Student > Master | 269 | 12% |
Student > Bachelor | 223 | 10% |
Student > Doctoral Student | 118 | 5% |
Other | 296 | 13% |
Unknown | 392 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 549 | 25% |
Medicine and Dentistry | 403 | 18% |
Biochemistry, Genetics and Molecular Biology | 344 | 15% |
Immunology and Microbiology | 300 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 50 | 2% |
Other | 155 | 7% |
Unknown | 431 | 19% |