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The ETS1 transcription factor is required for the development and cytokine-induced expansion of ILC2

Overview of attention for article published in The Journal of Experimental Medicine, April 2016
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  • Good Attention Score compared to outputs of the same age (71st percentile)

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Title
The ETS1 transcription factor is required for the development and cytokine-induced expansion of ILC2
Published in
The Journal of Experimental Medicine, April 2016
DOI 10.1084/jem.20150851
Pubmed ID
Authors

Erin C. Zook, Kevin Ramirez, Xiaohuan Guo, Grant van der Voort, Mikael Sigvardsson, Eric C. Svensson, Yang-Xin Fu, Barbara L. Kee

Abstract

Group 2 innate lymphoid cells (ILC2s) are a subset of ILCs that play a protective role in the response to helminth infection, but they also contribute to allergic lung inflammation. Here, we report that the deletion of the ETS1 transcription factor in lymphoid cells resulted in a loss of ILC2s in the bone marrow and lymph nodes and that ETS1 promotes the fitness of the common progenitor of all ILCs. ETS1-deficient ILC2 progenitors failed to up-regulate messenger RNA for the E protein transcription factor inhibitor ID2, a critical factor for ILCs, and these cells were unable to expand in cytokine-driven in vitro cultures. In vivo, ETS1 was required for the IL-33-induced accumulation of lung ILC2s and for the production of the T helper type 2 cytokines IL-5 and IL-13. IL-25 also failed to elicit an expansion of inflammatory ILC2s when these cells lacked ETS1. Our data reveal ETS1 as a critical regulator of ILC2 expansion and cytokine production and implicate ETS1 in the regulation ofId2at the inception of ILC2 development.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Greece 1 1%
Italy 1 1%
Germany 1 1%
Unknown 76 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 32%
Researcher 14 18%
Student > Master 6 8%
Student > Doctoral Student 5 6%
Student > Bachelor 4 5%
Other 6 8%
Unknown 19 24%
Readers by discipline Count As %
Immunology and Microbiology 21 27%
Agricultural and Biological Sciences 15 19%
Biochemistry, Genetics and Molecular Biology 12 15%
Medicine and Dentistry 6 8%
Engineering 3 4%
Other 3 4%
Unknown 19 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2018.
All research outputs
#6,753,240
of 25,371,288 outputs
Outputs from The Journal of Experimental Medicine
#5,820
of 11,597 outputs
Outputs of similar age
#89,715
of 316,333 outputs
Outputs of similar age from The Journal of Experimental Medicine
#35
of 49 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 11,597 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.4. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,333 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.