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Evidence-Based, Non-Surgical Treatments for Vitiligo

Overview of attention for article published in American Journal of Clinical Dermatology, December 2012
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Title
Evidence-Based, Non-Surgical Treatments for Vitiligo
Published in
American Journal of Clinical Dermatology, December 2012
DOI 10.2165/11630540-000000000-00000
Pubmed ID
Authors

Robert M. Bacigalupi, Anna Postolova, Ronald S. Davis

Abstract

Vitiligo is an acquired pigmentary disorder characterized by depigmented macules and patches secondary to the loss of functional melanocytes. It is a chronic disease that affects between 0.1% and 2% of the general population, affecting both sexes and all races. The appearance and the unpredictable course are psychologically and socially devastating. The success of current therapeutic options is limited. The objective of this review was to assess non-surgical treatments of vitiligo and to determine if comparing these studies can lead to (1) practical applications in the clinical setting and (2) recommendations for future research including study design and topics to be investigated further. Combination therapies were found to be more effective than monotherapy, and most combinations included a form of phototherapy, of which narrow-band-UVB was found to be most effective with the least adverse effects. Topical treatment with corticosteroids, immunomodulators, vitamin D analogs, and psoralens had mixed outcomes. Oral therapies including antioxidants were helpful adjuvants to treatment. Studies lacked consistent design, mechanism of disease assessment, and long-term follow-up. Sample size was also frequently limited. This review found that while several non-surgical therapies exist for the treatment of vitiligo, their usefulness, especially in the long term, is not well understood. Those studies that were able to elicit repigmentation often lacked an assessment on quality of life and/or patient satisfaction. More standardized methods of study design and assessment are needed to compare outcomes and make definitive conclusions on treatment effectiveness.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 23%
Student > Postgraduate 7 20%
Student > Bachelor 5 14%
Researcher 4 11%
Student > Ph. D. Student 4 11%
Other 3 9%
Unknown 4 11%
Readers by discipline Count As %
Medicine and Dentistry 17 49%
Pharmacology, Toxicology and Pharmaceutical Science 4 11%
Nursing and Health Professions 3 9%
Psychology 3 9%
Biochemistry, Genetics and Molecular Biology 2 6%
Other 2 6%
Unknown 4 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2012.
All research outputs
#20,657,128
of 25,374,917 outputs
Outputs from American Journal of Clinical Dermatology
#956
of 1,066 outputs
Outputs of similar age
#226,518
of 286,194 outputs
Outputs of similar age from American Journal of Clinical Dermatology
#15
of 17 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,066 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.5. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
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We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.