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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery
|
|---|---|
| Published in |
Nature Reviews Endocrinology, April 2016
|
| DOI | 10.1038/nrendo.2016.51 |
| Pubmed ID | |
| Authors |
Kaixin Zhou, Helle Krogh Pedersen, Adem Y. Dawed, Ewan R. Pearson |
| Abstract |
Genomic studies have greatly advanced our understanding of the multifactorial aetiology of type 2 diabetes mellitus (T2DM) as well as the multiple subtypes of monogenic diabetes mellitus. In this Review, we discuss the existing pharmacogenetic evidence in both monogenic diabetes mellitus and T2DM. We highlight mechanistic insights from the study of adverse effects and the efficacy of antidiabetic drugs. The identification of extreme sulfonylurea sensitivity in patients with diabetes mellitus owing to heterozygous mutations in HNF1A represents a clear example of how pharmacogenetics can direct patient care. However, pharmacogenomic studies of response to antidiabetic drugs in T2DM has yet to be translated into clinical practice, although some moderate genetic effects have now been described that merit follow-up in trials in which patients are selected according to genotype. We also discuss how future pharmacogenomic findings could provide insights into treatment response in diabetes mellitus that, in addition to other areas of human genetics, facilitates drug discovery and drug development for T2DM. |
X Demographics
The data shown below were collected from the profiles of 50 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 9 | 18% |
| United Kingdom | 6 | 12% |
| United States | 6 | 12% |
| Canada | 3 | 6% |
| Australia | 2 | 4% |
| Mexico | 2 | 4% |
| Dominican Republic | 1 | 2% |
| Italy | 1 | 2% |
| Brazil | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 19 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 25 | 50% |
| Scientists | 13 | 26% |
| Practitioners (doctors, other healthcare professionals) | 10 | 20% |
| Science communicators (journalists, bloggers, editors) | 2 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| France | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 143 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 23 | 16% |
| Student > Bachelor | 18 | 12% |
| Researcher | 17 | 12% |
| Student > Ph. D. Student | 17 | 12% |
| Student > Postgraduate | 10 | 7% |
| Other | 32 | 22% |
| Unknown | 29 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 38 | 26% |
| Pharmacology, Toxicology and Pharmaceutical Science | 17 | 12% |
| Agricultural and Biological Sciences | 16 | 11% |
| Biochemistry, Genetics and Molecular Biology | 15 | 10% |
| Chemistry | 6 | 4% |
| Other | 18 | 12% |
| Unknown | 36 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 42. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 June 2022.
All research outputs
#985,714
of 25,349,035 outputs
Outputs from Nature Reviews Endocrinology
#298
of 2,457 outputs
Outputs of similar age
#17,027
of 308,087 outputs
Outputs of similar age from Nature Reviews Endocrinology
#10
of 52 outputs
Altmetric has tracked 25,349,035 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,457 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.0. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 308,087 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.