| Title |
Role of transglutaminase 2 in celiac disease pathogenesis
|
|---|---|
| Published in |
Seminars in Immunopathology, March 2012
|
| DOI | 10.1007/s00281-012-0305-0 |
| Pubmed ID | |
| Authors |
Cornelius Klöck, Thomas R. DiRaimondo, Chaitan Khosla |
| Abstract |
A number of lines of evidence suggest that transglutaminase 2 (TG2) may be one of the earliest disease-relevant proteins to encounter immunotoxic gluten in the celiac gut. These and other investigations also suggest that the reaction catalyzed by TG2 on dietary gluten peptides is essential for the pathogenesis of celiac disease. If so, several questions are of critical significance. How is TG2 activated in the celiac gut? What are the disease-specific and general consequences of activating TG2? Can local inhibition of TG2 in the celiac intestine suppress gluten induced pathogenesis in a dose-responsive manner? And what are the long-term consequences of suppressing TG2 activity in the small intestinal mucosa? Answers to these questions will depend upon the development of judicious models and chemical tools. They also have the potential of yielding powerful next-generation drug candidates for treating this widespread but overlooked chronic disease. |
Mendeley readers
The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Germany | 2 | 1% |
| Brazil | 1 | <1% |
| Unknown | 141 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 37 | 25% |
| Researcher | 20 | 14% |
| Student > Bachelor | 19 | 13% |
| Student > Master | 16 | 11% |
| Student > Doctoral Student | 11 | 8% |
| Other | 19 | 13% |
| Unknown | 24 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 29 | 20% |
| Agricultural and Biological Sciences | 28 | 19% |
| Medicine and Dentistry | 25 | 17% |
| Chemistry | 9 | 6% |
| Immunology and Microbiology | 8 | 5% |
| Other | 21 | 14% |
| Unknown | 26 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 February 2018.
All research outputs
#3,484,692
of 25,837,817 outputs
Outputs from Seminars in Immunopathology
#95
of 721 outputs
Outputs of similar age
#21,196
of 174,781 outputs
Outputs of similar age from Seminars in Immunopathology
#1
of 5 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 721 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done well, scoring higher than 86% of its peers.
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We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them