| Title |
Sclerostin: Current Knowledge and Future Perspectives
|
|---|---|
| Published in |
Calcified Tissue International, May 2010
|
| DOI | 10.1007/s00223-010-9372-1 |
| Pubmed ID | |
| Authors |
M. J. C. Moester, S. E. Papapoulos, C. W. G. M. Löwik, R. L. van Bezooijen |
| Abstract |
In recent years study of rare human bone disorders has led to the identification of important signaling pathways that regulate bone formation. Such diseases include the bone sclerosing dysplasias sclerosteosis and van Buchem disease, which are due to deficiency of sclerostin, a protein secreted by osteocytes that inhibits bone formation by osteoblasts. The restricted expression pattern of sclerostin in the skeleton and the exclusive bone phenotype of good quality of patients with sclerosteosis and van Buchem disease provide the basis for the design of therapeutics that stimulate bone formation. We review here current knowledge of the regulation of the expression and formation of sclerostin, its mechanism of action, and its potential as a bone-building treatment for patients with osteoporosis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 224 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| Japan | 2 | <1% |
| Pakistan | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 218 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 44 | 20% |
| Researcher | 37 | 17% |
| Student > Master | 30 | 13% |
| Student > Doctoral Student | 17 | 8% |
| Student > Bachelor | 17 | 8% |
| Other | 48 | 21% |
| Unknown | 31 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 80 | 36% |
| Agricultural and Biological Sciences | 52 | 23% |
| Biochemistry, Genetics and Molecular Biology | 23 | 10% |
| Engineering | 10 | 4% |
| Sports and Recreations | 4 | 2% |
| Other | 19 | 8% |
| Unknown | 36 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2024.
All research outputs
#8,354,398
of 25,613,746 outputs
Outputs from Calcified Tissue International
#570
of 1,890 outputs
Outputs of similar age
#37,232
of 103,832 outputs
Outputs of similar age from Calcified Tissue International
#6
of 10 outputs
Altmetric has tracked 25,613,746 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 1,890 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 103,832 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.