| Title |
Magnetic nanoparticles for “smart liposomes”
|
|---|---|
| Published in |
European Biophysics Journal, July 2015
|
| DOI | 10.1007/s00249-015-1059-0 |
| Pubmed ID | |
| Authors |
Yoshitaka Nakayama, Mislav Mustapić, Haleh Ebrahimian, Pawel Wagner, Jung Ho Kim, Md Shahriar Al Hossain, Joseph Horvat, Boris Martinac |
| Abstract |
Liposomal drug delivery systems (LDDSs) are promising tools used for the treatment of diseases where highly toxic pharmacological agents are administered. Currently, destabilising LDDSs by a specific stimulus at a target site remains a major challenge. The bacterial mechanosensitive channel of large conductance (MscL) presents an excellent candidate biomolecule that could be employed as a remotely controlled pore-forming nanovalve for triggered drug release from LDDSs. In this study, we developed superparamagnetic nanoparticles for activation of the MscL nanovalves by magnetic field. Synthesised CoFe2O4 nanoparticles with the radius less than 10 nm were labelled by SH groups for attachment to MscL. Activation of MscL by magnetic field with the nanoparticles attached was examined by the patch clamp technique showing that the number of activated channels under ramp pressure increased upon application of the magnetic field. In addition, we have not observed any cytotoxicity of the nanoparticles in human cultured cells. Our study suggests the possibility of using magnetic nanoparticles as a specific trigger for activation of MscL nanovalves for drug release in LDDSs. |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Unknown | 47 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 23% |
| Student > Ph. D. Student | 9 | 19% |
| Student > Master | 7 | 15% |
| Student > Postgraduate | 4 | 8% |
| Student > Bachelor | 3 | 6% |
| Other | 6 | 13% |
| Unknown | 8 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 17% |
| Engineering | 6 | 13% |
| Materials Science | 6 | 13% |
| Chemistry | 4 | 8% |
| Agricultural and Biological Sciences | 3 | 6% |
| Other | 9 | 19% |
| Unknown | 12 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 April 2016.
All research outputs
#4,186,864
of 22,860,626 outputs
Outputs from European Biophysics Journal
#32
of 491 outputs
Outputs of similar age
#47,738
of 234,745 outputs
Outputs of similar age from European Biophysics Journal
#1
of 7 outputs
Altmetric has tracked 22,860,626 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 491 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 234,745 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them