Title |
Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice
|
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Published in |
Gut, March 2012
|
DOI | 10.1136/gutjnl-2011-300076 |
Pubmed ID | |
Authors |
Christian Sina, Simone Lipinski, Olga Gavrilova, Konrad Aden, Ateequr Rehman, Andreas Till, Andrea Rittger, Rainer Podschun, Ulf Meyer-Hoffert, Robert Haesler, Emilie Midtling, Katrin Pütsep, Michael A McGuckin, Stefan Schreiber, Paul Saftig, Philip Rosenstiel |
Abstract |
Cathepsin K is a lysosomal cysteine protease that has pleiotropic roles in bone resorption, arthritis, atherosclerosis, blood pressure regulation, obesity and cancer. Recently, it was demonstrated that cathepsin K-deficient (Ctsk(-/-) ) mice are less susceptible to experimental autoimmune arthritis and encephalomyelitis, which implies a functional role for cathepsin K in chronic inflammatory responses. Here, the authors address the relevance of cathepsin K in the intestinal immune response during chronic intestinal inflammation. |
Mendeley readers
Geographical breakdown
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Germany | 1 | 1% |
Unknown | 87 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 25 | 28% |
Student > Ph. D. Student | 15 | 17% |
Student > Master | 12 | 13% |
Other | 6 | 7% |
Professor > Associate Professor | 4 | 4% |
Other | 11 | 12% |
Unknown | 17 | 19% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 14 | 16% |
Immunology and Microbiology | 10 | 11% |
Biochemistry, Genetics and Molecular Biology | 7 | 8% |
Environmental Science | 1 | 1% |
Other | 7 | 8% |
Unknown | 20 | 22% |