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Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice

Overview of attention for article published in Gut, March 2012
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Title
Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice
Published in
Gut, March 2012
DOI 10.1136/gutjnl-2011-300076
Pubmed ID
Authors

Christian Sina, Simone Lipinski, Olga Gavrilova, Konrad Aden, Ateequr Rehman, Andreas Till, Andrea Rittger, Rainer Podschun, Ulf Meyer-Hoffert, Robert Haesler, Emilie Midtling, Katrin Pütsep, Michael A McGuckin, Stefan Schreiber, Paul Saftig, Philip Rosenstiel

Abstract

Cathepsin K is a lysosomal cysteine protease that has pleiotropic roles in bone resorption, arthritis, atherosclerosis, blood pressure regulation, obesity and cancer. Recently, it was demonstrated that cathepsin K-deficient (Ctsk(-/-) ) mice are less susceptible to experimental autoimmune arthritis and encephalomyelitis, which implies a functional role for cathepsin K in chronic inflammatory responses. Here, the authors address the relevance of cathepsin K in the intestinal immune response during chronic intestinal inflammation.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Netherlands 1 1%
Germany 1 1%
Unknown 87 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 25 28%
Student > Ph. D. Student 15 17%
Student > Master 12 13%
Other 6 7%
Professor > Associate Professor 4 4%
Other 11 12%
Unknown 17 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 31 34%
Medicine and Dentistry 14 16%
Immunology and Microbiology 10 11%
Biochemistry, Genetics and Molecular Biology 7 8%
Environmental Science 1 1%
Other 7 8%
Unknown 20 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2013.
All research outputs
#16,919,456
of 25,654,806 outputs
Outputs from Gut
#6,007
of 7,417 outputs
Outputs of similar age
#110,371
of 173,238 outputs
Outputs of similar age from Gut
#41
of 55 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,417 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.9. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 173,238 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.