Title |
Presence of functional cannabinoid receptors in human endocrine pancreas
|
---|---|
Published in |
Diabetologia, December 2007
|
DOI | 10.1007/s00125-007-0890-y |
Pubmed ID | |
Authors |
F. J. Bermúdez-Silva, J. Suárez, E. Baixeras, N. Cobo, D. Bautista, A. L. Cuesta-Muñoz, E. Fuentes, P. Juan-Pico, M. J. Castro, G. Milman, R. Mechoulam, A. Nadal, F. Rodríguez de Fonseca |
Abstract |
We examined the presence of functional cannabinoid receptors 1 and 2 (CB1, CB2) in isolated human islets, phenotyped the cells producing cannabinoid receptors and analysed the actions of selective cannabinoid receptor agonists on insulin, glucagon and somatostatin secretion in vitro. We also described the localisation on islet cells of: (1) the endocannabinoid-producing enzymes N-acyl-phosphatidyl ethanolamine-hydrolysing phospholipase D and diacylglycerol lipase; and (2) the endocannabinoid-degrading enzymes fatty acid amidohydrolase and monoacyl glycerol lipase. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Israel | 1 | <1% |
India | 1 | <1% |
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 132 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 22 | 16% |
Researcher | 20 | 15% |
Student > Bachelor | 18 | 13% |
Student > Master | 13 | 9% |
Student > Doctoral Student | 10 | 7% |
Other | 23 | 17% |
Unknown | 31 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 27 | 20% |
Agricultural and Biological Sciences | 27 | 20% |
Biochemistry, Genetics and Molecular Biology | 18 | 13% |
Psychology | 6 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
Other | 16 | 12% |
Unknown | 38 | 28% |