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Digestion by pepsin releases biologically active chromopeptides from C-phycocyanin, a blue-colored biliprotein of microalga Spirulina

Overview of attention for article published in Journal of Proteomics, April 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

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2 policy sources
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7 X users

Citations

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48 Dimensions

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104 Mendeley
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Title
Digestion by pepsin releases biologically active chromopeptides from C-phycocyanin, a blue-colored biliprotein of microalga Spirulina
Published in
Journal of Proteomics, April 2016
DOI 10.1016/j.jprot.2016.03.043
Pubmed ID
Authors

Simeon L. Minic, Dragana Stanic-Vucinic, Jelena Mihailovic, Maja Krstic, Milan R. Nikolic, Tanja Cirkovic Velickovic

Abstract

C-phycocyanin, the major protein of cyanobacteria Spirulina, possesses significant antioxidant, anti-cancer, anti-inflammatory and immunomodulatory effects, ascribed to covalently attach linear tetrapyrrole chromophore phycocyanobilin. There are no literature data about structure and biological activities of released peptides with bound chromophore in C-phycocyanin digest. This study aims to identify chromopeptides obtained after pepsin digestion of C-phycocyanin and to examine their bioactivities. C-phycocyanin is rapidly digested by pepsin in simulated gastric fluid. The structure of released chromopeptides was analyzed by high resolution tandem mass spectrometry and peptides varying in size from 2 to 13 amino acid residues were identified in both subunits of C-phycocyanin. Following separation by HPLC, chromopeptides were analyzed for potential bioactivities. It was shown that all five chromopeptide fractions have significant antioxidant and metal-chelating activities and show cytotoxic effect on human cervical adenocarcinoma and epithelial colonic cancer cell lines. In addition, chromopeptides protect human erythrocytes from free radical-induced hemolysis in antioxidative capacity-dependant manner. There was a positive correlation between antioxidative potency and other biological activities of chromopeptides. Digestion by pepsin releases biologically active chromopeptides from C-phycocyanin whose activity is mostly related to the antioxidative potency provided by chromophore.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Taiwan 1 <1%
Unknown 103 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 22 21%
Student > Ph. D. Student 17 16%
Researcher 11 11%
Student > Bachelor 8 8%
Student > Doctoral Student 6 6%
Other 15 14%
Unknown 25 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 27%
Biochemistry, Genetics and Molecular Biology 17 16%
Engineering 7 7%
Chemistry 4 4%
Medicine and Dentistry 3 3%
Other 9 9%
Unknown 36 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2021.
All research outputs
#3,322,821
of 25,374,917 outputs
Outputs from Journal of Proteomics
#150
of 3,461 outputs
Outputs of similar age
#51,417
of 315,832 outputs
Outputs of similar age from Journal of Proteomics
#8
of 99 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,461 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,832 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.