| Title |
Pooled exposure–response analyses and risk assessment for lung cancer in 10 cohorts of silica-exposed workers: an IARC multicentre study
|
|---|---|
| Published in |
Cancer Causes & Control, November 2001
|
| DOI | 10.1023/a:1012214102061 |
| Pubmed ID | |
| Authors |
Kyle Steenland, Andrea Mannetje, Paolo Boffetta, Leslie Stayner, Michael Attfield, Jingqiong Chen, Mustafa Dosemeci, Nicholas DeKlerk, Eva Hnizdo, Riitta Koskela, Harvey Checkoway |
| Abstract |
Silica is one of the most common occupational exposures worldwide. In 1997 the International Agency for Research on Cancer (IARC) classified inhaled crystalline silica as a human carcinogen (group 1), but acknowledged limitations in the epidemiologic data, including inconsistencies across studies and the lack of extensive exposure-response data. We have conducted a pooled exposure-response analysis of 10 silica-exposed cohorts to investigate lung cancer. The pooled cohort included 65,980 workers (44,160 miners, 21,820 nominees), and 1,072 lung cancer deaths (663 miners, 409 nonminers). Follow-up has been extended for five of these cohorts beyond published data. Quantitative exposure estimates by job and calendar time were adopted, modified, or developed to permit common analyses by respirable silica (mg/m3) across cohorts. The log of cumulative exposure, with a 15-year lag, was a strong predictor of lung cancer (p = 0.0001), with consistency across studies (test for heterogeneity, p = 0.34). Results for the log of cumulative exposure were consistent between underground mines and other facilities. Categorical analyses by quintile of cumulative exposure resulted in a monotonic trend with odds ratios of 1.0. 1.0, 1.3, 1.5, 1.6. Analyses using a spline curve also showed a monotonic increase in risk with increasing exposure. The estimated excess lifetime risk (through age 75) of lung cancer for a worker exposed from age 20 to 65 at 0.1 mg/m3 respirable crystalline silica (the permissible level in many countries) was 1.1-1.7%, above background risks of 3-6%. Our results support the decision by the IARC to classify inhaled silica in occupational settings as a carcinogen, and suggest that the current exposure limits in many countries may be inadequate. These data represent the first quantitative exposure-response analysis and risk assessment for silica using data from multiple studies. |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Spain | 1 | 1% |
| Korea, Republic of | 1 | 1% |
| Unknown | 87 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 15% |
| Student > Master | 10 | 11% |
| Student > Doctoral Student | 9 | 10% |
| Student > Ph. D. Student | 8 | 9% |
| Student > Bachelor | 7 | 8% |
| Other | 18 | 20% |
| Unknown | 25 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 31 | 34% |
| Environmental Science | 10 | 11% |
| Social Sciences | 5 | 5% |
| Nursing and Health Professions | 5 | 5% |
| Mathematics | 3 | 3% |
| Other | 11 | 12% |
| Unknown | 26 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2016.
All research outputs
#3,798,945
of 25,374,647 outputs
Outputs from Cancer Causes & Control
#425
of 2,266 outputs
Outputs of similar age
#4,323
of 45,943 outputs
Outputs of similar age from Cancer Causes & Control
#2
of 13 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,266 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one has done well, scoring higher than 80% of its peers.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.