Title |
How do we choose the best donor for T-cell-replete, HLA-haploidentical transplantation?
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Published in |
Journal of Hematology & Oncology, April 2016
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DOI | 10.1186/s13045-016-0265-2 |
Pubmed ID | |
Authors |
Ying-Jun Chang, Leo Luznik, Ephraim J. Fuchs, Xiao-Jun Huang |
Abstract |
In haploidentical stem cell transplantations (haplo-SCT), nearly all patients have more than one donor. A key issue in the haplo-SCT setting is the search for the best donor, because donor selection can significantly impact the incidences of acute and chronic graft-versus-host disease, transplant-related mortality, and relapse, in addition to overall survival. In this review, we focused on factors associated with transplant outcomes following unmanipulated haplo-SCT with anti-thymocyte globulin (ATG) or after T-cell-replete haplo-SCT with post-transplantation cyclophosphamide (PT/Cy). We summarized the effects of the primary factors, including donor-specific antibodies against human leukocyte antigens (HLA); donor age and gender; killer immunoglobulin-like receptor-ligand mismatches; and non-inherited maternal antigen mismatches. We also offered some expert recommendations and proposed an algorithm for selecting donors for unmanipulated haplo-SCT with ATG and for T-cell-replete haplo-SCT with PT/Cy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 1% |
Unknown | 74 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 14 | 19% |
Researcher | 14 | 19% |
Student > Master | 7 | 9% |
Student > Postgraduate | 6 | 8% |
Student > Bachelor | 6 | 8% |
Other | 16 | 21% |
Unknown | 12 | 16% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 42 | 56% |
Immunology and Microbiology | 5 | 7% |
Agricultural and Biological Sciences | 4 | 5% |
Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Engineering | 2 | 3% |
Other | 4 | 5% |
Unknown | 15 | 20% |