| Title |
How strontium ranelate, via opposite effects on bone resorption and formation, prevents osteoporosis
|
|---|---|
| Published in |
Osteoporosis International, September 2010
|
| DOI | 10.1007/s00198-010-1369-0 |
| Pubmed ID | |
| Authors |
P. J. Marie, D. Felsenberg, M. L. Brandi |
| Abstract |
Oestrogen deficiency increases the rate of bone remodelling which, in association with a negative remodelling balance (resorption exceeding formation), results in impaired bone architecture, mass and strength. Current anti-osteoporotic drugs act on bone remodelling by inhibiting bone resorption or by promoting its formation. An alternative therapeutic approach is based on the concept of inducing opposite effects on bone resorption and formation. One therapeutic agent, strontium ranelate, was shown to induce opposite effects on bone resorption and formation in pre-clinical studies and to reduce fracture risk in postmenopausal osteoporotic patients. How strontium ranelate acts to improve bone strength in humans remains a matter of debate, however. This review of the most recent pre-clinical and clinical studies is a critical analysis of strontium ranelate's action on bone resorption and formation and how it increases bone mass, microarchitecture and strength in postmenopausal osteoporotic women. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 85 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 14% |
| Student > Master | 12 | 14% |
| Student > Doctoral Student | 10 | 11% |
| Student > Ph. D. Student | 10 | 11% |
| Student > Bachelor | 7 | 8% |
| Other | 15 | 17% |
| Unknown | 21 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 22% |
| Materials Science | 11 | 13% |
| Agricultural and Biological Sciences | 8 | 9% |
| Engineering | 6 | 7% |
| Chemistry | 6 | 7% |
| Other | 11 | 13% |
| Unknown | 26 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2012.
All research outputs
#17,656,184
of 22,663,969 outputs
Outputs from Osteoporosis International
#2,522
of 3,596 outputs
Outputs of similar age
#83,768
of 94,130 outputs
Outputs of similar age from Osteoporosis International
#18
of 25 outputs
Altmetric has tracked 22,663,969 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,596 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.