| Title |
Molecular subgroups of medulloblastoma: the current consensus
|
|---|---|
| Published in |
Acta Neuropathologica, December 2011
|
| DOI | 10.1007/s00401-011-0922-z |
| Pubmed ID | |
| Authors |
Michael D. Taylor, Paul A. Northcott, Andrey Korshunov, Marc Remke, Yoon-Jae Cho, Steven C. Clifford, Charles G. Eberhart, D. Williams Parsons, Stefan Rutkowski, Amar Gajjar, David W. Ellison, Peter Lichter, Richard J. Gilbertson, Scott L. Pomeroy, Marcel Kool, Stefan M. Pfister |
| Abstract |
Medulloblastoma, a small blue cell malignancy of the cerebellum, is a major cause of morbidity and mortality in pediatric oncology. Current mechanisms for clinical prognostication and stratification include clinical factors (age, presence of metastases, and extent of resection) as well as histological subgrouping (classic, desmoplastic, and large cell/anaplastic histology). Transcriptional profiling studies of medulloblastoma cohorts from several research groups around the globe have suggested the existence of multiple distinct molecular subgroups that differ in their demographics, transcriptomes, somatic genetic events, and clinical outcomes. Variations in the number, composition, and nature of the subgroups between studies brought about a consensus conference in Boston in the fall of 2010. Discussants at the conference came to a consensus that the evidence supported the existence of four main subgroups of medulloblastoma (Wnt, Shh, Group 3, and Group 4). Participants outlined the demographic, transcriptional, genetic, and clinical differences between the four subgroups. While it is anticipated that the molecular classification of medulloblastoma will continue to evolve and diversify in the future as larger cohorts are studied at greater depth, herein we outline the current consensus nomenclature, and the differences between the medulloblastoma subgroups. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Croatia | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,238 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | <1% |
| United Kingdom | 4 | <1% |
| Germany | 3 | <1% |
| Japan | 3 | <1% |
| Netherlands | 2 | <1% |
| Canada | 2 | <1% |
| Brazil | 1 | <1% |
| Czechia | 1 | <1% |
| Italy | 1 | <1% |
| Other | 4 | <1% |
| Unknown | 1207 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 182 | 15% |
| Student > Bachelor | 154 | 12% |
| Researcher | 149 | 12% |
| Student > Master | 123 | 10% |
| Other | 89 | 7% |
| Other | 248 | 20% |
| Unknown | 293 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 356 | 29% |
| Biochemistry, Genetics and Molecular Biology | 200 | 16% |
| Agricultural and Biological Sciences | 182 | 15% |
| Neuroscience | 61 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 1% |
| Other | 100 | 8% |
| Unknown | 324 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 37. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 August 2023.
All research outputs
#1,094,996
of 25,339,932 outputs
Outputs from Acta Neuropathologica
#170
of 2,541 outputs
Outputs of similar age
#6,495
of 252,181 outputs
Outputs of similar age from Acta Neuropathologica
#2
of 27 outputs
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