Title |
Epigenetics, Asthma, and Allergic Diseases: A Review of the Latest Advancements
|
---|---|
Published in |
Current Allergy and Asthma Reports, March 2012
|
DOI | 10.1007/s11882-012-0257-4 |
Pubmed ID | |
Authors |
Stephanie Lovinsky-Desir, Rachel L. Miller |
Abstract |
Environmental epigenetic regulation in asthma and allergic disease is an exciting area that has gained a great deal of scientific momentum in recent years. Environmental exposures, including prenatal maternal smoking, have been associated with asthma-related outcomes that may be explained by epigenetic regulation. In addition, several known allergy and asthma genes have been found to be susceptible to epigenetic regulation. We review the latest experimental and translational studies that have been published this past year in several areas, including 1) characterization of environmental asthma triggers that induce epigenetic changes, 2) characterization of allergic immune and regulatory pathways important to asthma that undergo epigenetic regulation, 3) evidence of active epigenetic regulation in asthma experimental models and the production of asthma biomarkers, 4) evidence of transmission of an asthma-related phenotype across multiple generations, and 5) "pharmaco-epigenetics." The field has certainly advanced significantly in the past year. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | <1% |
Hong Kong | 1 | <1% |
Tunisia | 1 | <1% |
Canada | 1 | <1% |
Spain | 1 | <1% |
Unknown | 130 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 26 | 19% |
Researcher | 21 | 16% |
Student > Master | 14 | 10% |
Student > Bachelor | 14 | 10% |
Student > Doctoral Student | 9 | 7% |
Other | 21 | 16% |
Unknown | 30 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 31 | 23% |
Agricultural and Biological Sciences | 24 | 18% |
Biochemistry, Genetics and Molecular Biology | 17 | 13% |
Environmental Science | 5 | 4% |
Nursing and Health Professions | 4 | 3% |
Other | 20 | 15% |
Unknown | 34 | 25% |