Chapter title |
Endocannabinoids
|
---|---|
Chapter number | 16 |
Book title |
Endocannabinoids
|
Published in |
Handbook of experimental pharmacology, January 2015
|
DOI | 10.1007/978-3-319-20825-1_16 |
Pubmed ID | |
Book ISBNs |
978-3-31-920824-4, 978-3-31-920825-1
|
Authors |
Velasco, Guillermo, Sánchez, Cristina, Guzmán, Manuel, Guillermo Velasco, Cristina Sánchez, Manuel Guzmán |
Editors |
Roger G. Pertwee |
Abstract |
A large body of evidence shows that cannabinoids, in addition to their well-known palliative effects on some cancer-associated symptoms, can reduce tumour growth in animal models of cancer. They do so by modulating key cell signalling pathways involved in the control of cancer cell proliferation and survival. In addition, cannabinoids inhibit angiogenesis and cell proliferation in different types of tumours in laboratory animals. By contrast, little is known about the biological role of the endocannabinoid system in cancer physio-pathology, and several studies suggest that it may be over-activated in cancer. In this review, we discuss our current understanding of cannabinoids as antitumour agents, focusing on recent advances in the molecular mechanisms of action, including resistance mechanisms and opportunities for combination therapy approaches. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 82 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 16 | 20% |
Student > Ph. D. Student | 12 | 15% |
Student > Master | 10 | 12% |
Student > Bachelor | 7 | 9% |
Other | 6 | 7% |
Other | 11 | 13% |
Unknown | 20 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 21% |
Biochemistry, Genetics and Molecular Biology | 12 | 15% |
Agricultural and Biological Sciences | 5 | 6% |
Neuroscience | 5 | 6% |
Nursing and Health Professions | 3 | 4% |
Other | 14 | 17% |
Unknown | 26 | 32% |