Title |
Emerging pan-resistance in Trichosporon species: a case report
|
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Published in |
BMC Infectious Diseases, April 2016
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DOI | 10.1186/s12879-016-1477-3 |
Pubmed ID | |
Authors |
Claudy Oliveira dos Santos, Jan G. Zijlstra, Robert J. Porte, Greetje A. Kampinga, Anne D. van Diepeningen, Bhanu Sinha, Erik Bathoorn |
Abstract |
Trichosporon species are ubiquitously spread and known to be part of the normal human flora of the skin and gastrointestinal tract. Trichosporon spp. normally cause superficial infections. However, in the past decade Trichosporon spp. are emerging as opportunistic agents of invasive fungal infections, particularly in severely immunocompromised patients. Clinical isolates are usually sensitive to triazoles, but strains resistant to multiple triazoles have been reported. We report a high-level pan-azole resistant Trichosporon dermatis isolate causing an invasive cholangitis in a patient after liver re-transplantation. This infection occurred despite of fluconazole and low dose amphotericin B prophylaxis, and treatment with combined liposomal amphotericin B and voriconazole failed. This case and recent reports in literature show that not only bacteria are evolving towards pan-resistance, but also pathogenic yeasts. Prudent use of antifungals is important to withstand emerging antifungal resistance. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 49 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 10 | 20% |
Researcher | 8 | 16% |
Student > Bachelor | 6 | 12% |
Student > Postgraduate | 5 | 10% |
Other | 4 | 8% |
Other | 10 | 20% |
Unknown | 6 | 12% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 16 | 33% |
Agricultural and Biological Sciences | 8 | 16% |
Immunology and Microbiology | 6 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Other | 5 | 10% |
Unknown | 8 | 16% |