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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Nuclear factor one B ( NFIB ) encodes a subtype-specific tumour suppressor in glioblastoma
|
|---|---|
| Published in |
Oncotarget, April 2016
|
| DOI | 10.18632/oncotarget.8720 |
| Pubmed ID | |
| Authors |
Brett W. Stringer, Jens Bunt, Bryan W. Day, Guy Barry, Paul R. Jamieson, Kathleen S. Ensbey, Zara C. Bruce, Kate Goasdoué, Hélène Vidal, Sara Charmsaz, Fiona M. Smith, Leanne T. Cooper, Michael Piper, Andrew W. Boyd, Linda J. Richards |
| Abstract |
Glioblastoma (GBM) is an essentially incurable and rapidly fatal cancer, with few markers predicting a favourable prognosis. Here we report that the transcription factor NFIB is associated with significantly improved survival in GBM. NFIB expression correlates inversely with astrocytoma grade and is lowest in mesenchymal GBM. Ectopic expression of NFIB in low-passage, patient-derived classical and mesenchymal subtype GBM cells inhibits tumourigenesis. Ectopic NFIB expression activated phospho-STAT3 signalling only in classical and mesenchymal GBM cells, suggesting a mechanism through which NFIB may exert its context-dependent tumour suppressor activity. Finally, NFIB expression can be induced in GBM cells by drug treatment with beneficial effects. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 25% |
| Portugal | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Unknown | 48 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 20% |
| Student > Bachelor | 9 | 18% |
| Student > Master | 6 | 12% |
| Researcher | 6 | 12% |
| Student > Doctoral Student | 3 | 6% |
| Other | 4 | 8% |
| Unknown | 11 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 18 | 37% |
| Agricultural and Biological Sciences | 7 | 14% |
| Neuroscience | 6 | 12% |
| Medicine and Dentistry | 5 | 10% |
| Unspecified | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 12 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2017.
All research outputs
#2,827,400
of 22,862,742 outputs
Outputs from Oncotarget
#1,134
of 14,326 outputs
Outputs of similar age
#47,320
of 300,866 outputs
Outputs of similar age from Oncotarget
#57
of 1,283 outputs
Altmetric has tracked 22,862,742 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,326 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 300,866 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 1,283 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.