| Title |
Exploring the cancer genome in the era of next-generation sequencing
|
|---|---|
| Published in |
Frontiers of Medicine, March 2012
|
| DOI | 10.1007/s11684-012-0182-x |
| Pubmed ID | |
| Authors |
Hui Dong, Shengyue Wang |
| Abstract |
The emergence of next-generation sequencing technologies has led to dramatic advances in cancer genome studies. The increased efficiency and resolution of next-generation sequencing greatly facilitate the detection of genetic, genomic, and epigenomic alterations, such as single nucleotide mutations, small insertions and deletions, chromosomal rearrangements, copy number variations, and DNA methylation. Comprehensive analysis of cancer genomes through approaches of whole genome, exome, and transcriptome sequencing has significantly improved the understanding of cancer biology, diagnosis, and therapy. The present study briefly reviews the recent pioneering studies on cancer genome sequencing and provides an unprecedented insight into the landscape of genomic alterations in human sporadic cancers. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Australia | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 2% |
| Netherlands | 1 | 2% |
| Chile | 1 | 2% |
| United Kingdom | 1 | 2% |
| Mexico | 1 | 2% |
| Unknown | 59 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 28% |
| Student > Master | 10 | 16% |
| Student > Ph. D. Student | 9 | 14% |
| Professor > Associate Professor | 6 | 9% |
| Student > Bachelor | 5 | 8% |
| Other | 13 | 20% |
| Unknown | 3 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 30 | 47% |
| Medicine and Dentistry | 14 | 22% |
| Biochemistry, Genetics and Molecular Biology | 10 | 16% |
| Computer Science | 4 | 6% |
| Social Sciences | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 4 | 6% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2012.
All research outputs
#15,242,847
of 22,664,267 outputs
Outputs from Frontiers of Medicine
#168
of 339 outputs
Outputs of similar age
#102,486
of 161,111 outputs
Outputs of similar age from Frontiers of Medicine
#5
of 6 outputs
Altmetric has tracked 22,664,267 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 339 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 161,111 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.