| Title |
Antihyperlipidemic and Antioxidant Activities of Edible Tunisian Ficus carica L. Fruits in High Fat Diet-Induced Hyperlipidemic Rats
|
|---|---|
| Published in |
Plant Foods for Human Nutrition, April 2016
|
| DOI | 10.1007/s11130-016-0541-x |
| Pubmed ID | |
| Authors |
Olfa Belguith-Hadriche, Sonda Ammar, Maria del Mar Contreras, Mouna Turki, Antonio Segura-Carretero, Abdelfattah El Feki, Fatma Makni-Ayedi, Mohamed Bouaziz |
| Abstract |
The phenolic constituents of the aqueous-ethanolic extract of Tunisian Ficus carica (F. carica) fruit (FE) and its antihyperlipidemic and antioxidant activities in high-fat diet-induced hyperlipidemic rats (HFD) were evaluated. The obtained results demonstrated that the FE improved the lipid profile by decreasing the total cholesterol, triglyceride, low-density lipoprotein cholesterol and increasing high-density lipoprotein cholesterol levels. It also reduced the content of thiobarbituric acid-reactive substances and increased the antioxidant enzymes in liver, heart and kidney in HFD-fed rats. These antihyperlipidemic effects and in vivo antioxidative effects correlated with the in vitro phenolic content scavenging ability. Thus, the major phenolic compounds were identified using reversed-phase ultra-high-performance liquid chromatography (RP-UHPLC) coupled with two detection systems: diode-array detection (DAD) and quadrupole time-of-flight (QTOF) mass spectrometry (MS). Therefore, in the negative ionization mode, 28 phenolic compounds, including hydroxybenzoic acids, hydroxycinnamic acids, flavanoids and hydroxycoumarins were characterized. Dihydroxybenzoic acid di-pentoside, the flavonol quercetin 3-O-rutinoside and the flavone assigned as apigenin 8-C-glucoside were the main representative compounds in 'Tounsi' fruits. This work was complemented by the detection of seven other phenolic compounds in the positive ionization mode, including anthocyanins and furanocoumarins. Overall, these results have shown that the FE has a significant hypocholesterolemic effect and antioxidant activity in HFD-fed rats. This beneficial effect may be partly due to these phenolic constituents, especially vitexin, dihydroxybenzoic acid di-pentoside as well as rutin. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 93 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 17% |
| Student > Ph. D. Student | 12 | 13% |
| Student > Bachelor | 11 | 12% |
| Researcher | 6 | 6% |
| Professor | 4 | 4% |
| Other | 14 | 15% |
| Unknown | 30 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 15% |
| Biochemistry, Genetics and Molecular Biology | 9 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 9% |
| Medicine and Dentistry | 8 | 9% |
| Chemistry | 7 | 8% |
| Other | 8 | 9% |
| Unknown | 39 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2016.
All research outputs
#18,451,892
of 22,862,742 outputs
Outputs from Plant Foods for Human Nutrition
#537
of 703 outputs
Outputs of similar age
#197,903
of 269,982 outputs
Outputs of similar age from Plant Foods for Human Nutrition
#6
of 9 outputs
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