| Title |
Microglia in the Cerebral Cortex in Autism
|
|---|---|
| Published in |
Journal of Autism and Developmental Disorders, March 2012
|
| DOI | 10.1007/s10803-012-1513-0 |
| Pubmed ID | |
| Authors |
Nicole A. Tetreault, Atiya Y. Hakeem, Sue Jiang, Brian A. Williams, Elizabeth Allman, Barbara J. Wold, John M. Allman |
| Abstract |
We immunocytochemically identified microglia in fronto-insular (FI) and visual cortex (VC) in autopsy brains of well-phenotyped subjects with autism and matched controls, and stereologically quantified the microglial densities. Densities were determined blind to phenotype using an optical fractionator probe. In FI, individuals with autism had significantly more microglia compared to controls (p = 0.02). One such subject had a microglial density in FI within the control range and was also an outlier behaviorally with respect to other subjects with autism. In VC, microglial densities were also significantly greater in individuals with autism versus controls (p = 0.0002). Since we observed increased densities of microglia in two functionally and anatomically disparate cortical areas, we suggest that these immune cells are probably denser throughout cerebral cortex in brains of people with autism. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 20% |
| Unknown | 4 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Scientists | 1 | 20% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 270 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 1% |
| Iran, Islamic Republic of | 1 | <1% |
| Japan | 1 | <1% |
| Finland | 1 | <1% |
| Unknown | 263 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 53 | 20% |
| Student > Bachelor | 38 | 14% |
| Researcher | 33 | 12% |
| Student > Master | 26 | 10% |
| Student > Doctoral Student | 17 | 6% |
| Other | 41 | 15% |
| Unknown | 62 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 65 | 24% |
| Agricultural and Biological Sciences | 51 | 19% |
| Medicine and Dentistry | 32 | 12% |
| Biochemistry, Genetics and Molecular Biology | 18 | 7% |
| Psychology | 9 | 3% |
| Other | 29 | 11% |
| Unknown | 66 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2023.
All research outputs
#3,451,535
of 25,654,806 outputs
Outputs from Journal of Autism and Developmental Disorders
#1,459
of 5,484 outputs
Outputs of similar age
#21,077
of 173,659 outputs
Outputs of similar age from Journal of Autism and Developmental Disorders
#17
of 66 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,484 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.4. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 173,659 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.