You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Selenium and vitamin E together improve intestinal epithelial barrier function and alleviate oxidative stress in heat‐stressed pigs
|
|---|---|
| Published in |
Experimental Physiology, May 2016
|
| DOI | 10.1113/ep085746 |
| Pubmed ID | |
| Authors |
Fan Liu, Jeremy J Cottrell, John B Furness, Leni R Rivera, Fletcher W Kelly, Udani Wijesiriwardana, Ruslan V Pustovit, Linda J Fothergill, David M Bravo, Pietro Celi, Brian J Leury, Nicholas K Gabler, Frank R Dunshea |
| Abstract |
Heat stress compromises intestinal epithelial barrier integrity of mammals through mechanisms that may include oxidative stress. Our objective was to test whether dietary supplementation with antioxidants, selenium (Se) and Vitamin E (VE), protects intestinal epithelial barrier integrity in heat stressed pigs. Female growing pigs (n = 48) were randomly assigned to four diets containing from 0.2 ppm Se and 17 IU kg(-1) VE (control, NRC recommended), to 1.0 ppm Se and 200 IU kg(-1) VE for 14 days. Six pigs from each dietary treatment were then exposed to either thermoneutral 20°C or heat stress (35°C, 09.00-17.00/ 28°C, overnight) conditions for two days. Trans-epithelial electrical resistance (TER) and FITC-dextran (4 kDa; FD4) permeability were measured in isolated jejunum and ileum using Ussing chambers. Rectal temperature, respiration rate, and intestinal HSP70 mRNA abundance increased (all P < 0.001), and respiratory alkalosis occurred, suggesting that pigs were heat stressed. Heat stress also increased FD4 permeability and decreased TER (both P<0.01). These changes were associated with changes indicative of oxidative stress, a decreased glutathione peroxidase (GPX) activity and an increased glutathione disulfide (GSSG): glutathione (GSH) ratio (both P < 0.05). With increasing dosage of Se and VE, GPX-2 mRNA (P = 0.003) and GPX activity (P = 0.049) linearly increased, and the GSSG:GSH ratio linearly decreased (P = 0.037) and the impacts of heat stress on intestinal barrier function were reduced (P < 0.05 for both TER and FD4 permeability). In conclusion, an increase of dietary Se and VE mitigated heat stress impacts on intestinal barrier integrity, associated with a reduction in oxidative stress in pigs. This article is protected by copyright. All rights reserved. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 116 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 15% |
| Researcher | 16 | 14% |
| Student > Master | 13 | 11% |
| Student > Doctoral Student | 9 | 8% |
| Student > Bachelor | 9 | 8% |
| Other | 15 | 13% |
| Unknown | 37 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 29% |
| Veterinary Science and Veterinary Medicine | 11 | 9% |
| Medicine and Dentistry | 7 | 6% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Nursing and Health Professions | 2 | 2% |
| Other | 12 | 10% |
| Unknown | 44 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2016.
All research outputs
#3,022,499
of 25,457,297 outputs
Outputs from Experimental Physiology
#360
of 2,530 outputs
Outputs of similar age
#46,948
of 319,272 outputs
Outputs of similar age from Experimental Physiology
#8
of 33 outputs
Altmetric has tracked 25,457,297 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,530 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.5. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,272 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.