Title |
Low prevalence of human papillomavirus in oral cavity squamous cell carcinoma in Queensland, Australia
|
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Published in |
Australian & New Zealand Journal of Surgery, April 2016
|
DOI | 10.1111/ans.13607 |
Pubmed ID | |
Authors |
Sarah Emmett, Glenn Jenkins, Samuel Boros, David C. Whiteman, Benedict Panizza, Annika Antonsson |
Abstract |
While human papillomavirus (HPV) is an accepted risk factor for oropharyngeal squamous cell carcinoma (SCC), its aetiological role in oral cavity SCC remains unclear. This study aimed to determine the HPV prevalence in an Australian population. DNA was extracted from 63 formalin-fixed paraffin-embedded tumour specimens histologically confirmed as SCC of the oral cavity, diagnosed during 2006-2012. Clinical data were extracted from medical records. HPV presence was determined by polymerase chain reaction. Positive samples were typed by sequencing. Immunohistochemistry was used to assess p16(INK4A) , p53, pRB, Ki67, Cyclin D1 and p21(WAF1) expression. Five of the 63 tumours (8%) were positive for HPV DNA (three HPV-16 positive and two HPV-18 positive). Two tumours overexpressed p16(INK4A) (3%) and one of these was also HPV positive. Overexpression of Cyclin D1 correlated significantly with tumour recurrence (P = 0.029) and death (P = 0.002). This study has identified a low prevalence of high-risk HPV in Queensland, Australia. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 34 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Professor | 5 | 15% |
Student > Doctoral Student | 4 | 12% |
Professor > Associate Professor | 3 | 9% |
Student > Bachelor | 2 | 6% |
Student > Postgraduate | 2 | 6% |
Other | 6 | 18% |
Unknown | 12 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 44% |
Social Sciences | 2 | 6% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Earth and Planetary Sciences | 1 | 3% |
Chemical Engineering | 1 | 3% |
Other | 2 | 6% |
Unknown | 12 | 35% |