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Epstein–Barr virus latency type and spontaneous reactivation predict lytic induction levels

Overview of attention for article published in Biochemical & Biophysical Research Communications, April 2016
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Title
Epstein–Barr virus latency type and spontaneous reactivation predict lytic induction levels
Published in
Biochemical & Biophysical Research Communications, April 2016
DOI 10.1016/j.bbrc.2016.04.070
Pubmed ID
Authors

An T Phan, Samantha G Fernandez, Jessica J Somberg, Kristin M Keck, Jj L Miranda

Abstract

The human Epstein-Barr virus (EBV) evades the immune system by entering a transcriptionally latent phase in B cells. EBV in tumor cells express distinct patterns of genes referred to as latency types. Viruses in tumor cells also display varying levels of lytic transcription resulting from spontaneous reactivation out of latency. We measured this dynamic range of lytic transcription with RNA deep sequencing and observed no correlation with EBV latency types among genetically different viruses, but type I cell lines reveal more spontaneous reactivation than isogenic type III cultures. We further determined that latency type and spontaneous reactivation levels predict the relative amount of induced reactivation generated by cytotoxic chemotherapy drugs. Our work has potential implications for personalizing medicine against EBV-transformed malignancies. Identifying latency type or measuring spontaneous reactivation may provide predictive power in treatment contexts where viral production should be either avoided or coerced.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 21%
Student > Master 4 12%
Student > Doctoral Student 2 6%
Other 2 6%
Researcher 2 6%
Other 6 18%
Unknown 11 32%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 21%
Agricultural and Biological Sciences 7 21%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Medicine and Dentistry 2 6%
Immunology and Microbiology 2 6%
Other 3 9%
Unknown 11 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2016.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Biochemical & Biophysical Research Communications
#22,085
of 26,637 outputs
Outputs of similar age
#221,321
of 297,137 outputs
Outputs of similar age from Biochemical & Biophysical Research Communications
#128
of 268 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 26,637 research outputs from this source. They receive a mean Attention Score of 4.5. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,137 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 268 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.