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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genetic and Pharmacologic Inhibition of β-Catenin Targets Imatinib-Resistant Leukemia Stem Cells in CML
|
|---|---|
| Published in |
Cell Stem Cell, April 2012
|
| DOI | 10.1016/j.stem.2012.02.017 |
| Pubmed ID | |
| Authors |
Florian H. Heidel, Lars Bullinger, Zhaohui Feng, Zhu Wang, Tobias A. Neff, Lauren Stein, Demetrios Kalaitzidis, Steven W. Lane, Scott A. Armstrong |
| Abstract |
A key characteristic of hematopoietic stem cells (HSCs) is the ability to self-renew. Genetic deletion of β-catenin during fetal HSC development leads to impairment of self-renewal while β-catenin is dispensable in fully developed adult HSCs. Whether β-catenin is required for maintenance of fully developed CML leukemia stem cells (LSCs) is unknown. Here, we use a conditional mouse model to show that deletion of β-catenin after CML initiation does not lead to a significant increase in survival. However, deletion of β-catenin synergizes with imatinib (IM) to delay disease recurrence after imatinib discontinuation and to abrogate CML stem cells. These effects can be mimicked by pharmacologic inhibition of β-catenin via modulation of prostaglandin signaling. Treatment with the cyclooxygenase inhibitor indomethacin reduces β-catenin levels and leads to a reduction in LSCs. In conclusion, inhibiting β-catenin by genetic inactivation or pharmacologic modulation is an effective combination therapy with imatinib and targets CML stem cells. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Saudi Arabia | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 154 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 1% |
| Germany | 1 | <1% |
| Netherlands | 1 | <1% |
| Austria | 1 | <1% |
| Portugal | 1 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Argentina | 1 | <1% |
| United States | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 144 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 23% |
| Researcher | 31 | 20% |
| Student > Master | 14 | 9% |
| Other | 11 | 7% |
| Student > Doctoral Student | 10 | 6% |
| Other | 26 | 17% |
| Unknown | 26 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 54 | 35% |
| Medicine and Dentistry | 29 | 19% |
| Biochemistry, Genetics and Molecular Biology | 27 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Immunology and Microbiology | 3 | 2% |
| Other | 10 | 6% |
| Unknown | 26 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2017.
All research outputs
#2,966,263
of 25,374,917 outputs
Outputs from Cell Stem Cell
#1,500
of 2,823 outputs
Outputs of similar age
#18,074
of 173,050 outputs
Outputs of similar age from Cell Stem Cell
#23
of 48 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,823 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 48.5. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 173,050 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.