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Risk factors for metachronous colorectal cancer following a primary colorectal cancer: A prospective cohort study

Overview of attention for article published in International Journal of Cancer, May 2016
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Title
Risk factors for metachronous colorectal cancer following a primary colorectal cancer: A prospective cohort study
Published in
International Journal of Cancer, May 2016
DOI 10.1002/ijc.30153
Pubmed ID
Authors

Harindra Jayasekara, Jeanette C Reece, Daniel D Buchanan, Christophe Rosty, S Ghazaleh Dashti, Driss Ait Ouakrim, Ingrid M Winship, Finlay A Macrae, Alex Boussioutas, Graham G Giles, Dennis J Ahnen, Jan Lowery, Graham Casey, Robert W Haile, Steven Gallinger, Loic Le Marchand, Polly A Newcomb, Noralane M Lindor, John L Hopper, Susan Parry, Mark A Jenkins, Aung Ko Win

Abstract

Individuals diagnosed with colorectal cancer (CRC) are at risk of developing a metachronous colorectal cancer. We examined the associations between personal, tumour-related and lifestyle risk factors, and risk of metachronous CRC. A total of 7,863 participants with incident colon or rectal cancer who were recruited in the USA, Canada and Australia to the Colon Cancer Family Registry during 1997-2012, except those identified as high-risk e.g. Lynch syndrome, were followed up approximately every 5 years. We estimated the risk of metachronous CRC, defined as the first new primary CRC following an interval of at least one year after the initial colorectal cancer diagnosis. Observation time started at the age at diagnosis of the initial CRC and ended at the age at diagnosis of the metachronous CRC, last contact or death whichever occurred earliest, or were censored at the age at diagnosis of any metachronous colorectal adenoma. Cox regression was used to derive hazard ratios (HRs) and 95% confidence intervals (CIs). During a mean follow-up of 6.6 years, 142 (1.81%) metachronous colorectal cancers were diagnosed (mean age at diagnosis 59.8; incidence 2.7/1000 person-years). An increased risk of metachronous CRC was associated with the presence of a synchronous CRC (HR=2.73; 95% CI: 1.30-5.72) and the location of cancer in the proximal colon at initial diagnosis (compared with distal colon or rectum, HR=4.16; 95% CI: 2.80-6.18). The presence of a synchronous CRC and the location of the initial CRC might be useful for deciding the intensity of surveillance colonoscopy for individuals diagnosed with CRC. This article is protected by copyright. All rights reserved.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Other 8 19%
Student > Ph. D. Student 5 12%
Student > Bachelor 4 10%
Researcher 3 7%
Student > Master 3 7%
Other 8 19%
Unknown 11 26%
Readers by discipline Count As %
Medicine and Dentistry 14 33%
Social Sciences 4 10%
Agricultural and Biological Sciences 3 7%
Biochemistry, Genetics and Molecular Biology 3 7%
Computer Science 3 7%
Other 2 5%
Unknown 13 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2016.
All research outputs
#14,927,237
of 24,484,013 outputs
Outputs from International Journal of Cancer
#9,523
of 12,084 outputs
Outputs of similar age
#159,118
of 307,040 outputs
Outputs of similar age from International Journal of Cancer
#58
of 96 outputs
Altmetric has tracked 24,484,013 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 12,084 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,040 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 96 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.