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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor
|
|---|---|
| Published in |
Nature Communications, April 2016
|
| DOI | 10.1038/ncomms11222 |
| Pubmed ID | |
| Authors |
Camille Sayou, Max H. Nanao, Marc Jamin, David Posé, Emmanuel Thévenon, Laura Grégoire, Gabrielle Tichtinsky, Grégoire Denay, Felix Ott, Marta Peirats Llobet, Markus Schmid, Renaud Dumas, François Parcy |
| Abstract |
Deciphering the mechanisms directing transcription factors (TFs) to specific genome regions is essential to understand and predict transcriptional regulation. TFs recognize short DNA motifs primarily through their DNA-binding domain. Some TFs also possess an oligomerization domain suspected to potentiate DNA binding but for which the genome-wide influence remains poorly understood. Here we focus on the LEAFY transcription factor, a master regulator of flower development in angiosperms. We have determined the crystal structure of its conserved amino-terminal domain, revealing an unanticipated Sterile Alpha Motif oligomerization domain. We show that this domain is essential to LEAFY floral function. Moreover, combined biochemical and genome-wide assays suggest that oligomerization is required for LEAFY to access regions with low-affinity binding sites or closed chromatin. This finding shows that domains that do not directly contact DNA can nevertheless have a profound impact on the DNA binding landscape of a TF. |
X Demographics
The data shown below were collected from the profiles of 24 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 13% |
| Switzerland | 2 | 8% |
| France | 2 | 8% |
| Germany | 2 | 8% |
| United Kingdom | 2 | 8% |
| Denmark | 1 | 4% |
| Australia | 1 | 4% |
| Norway | 1 | 4% |
| Spain | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 9 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 50% |
| Scientists | 12 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 1% |
| Netherlands | 1 | 1% |
| Unknown | 87 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 22% |
| Student > Ph. D. Student | 19 | 21% |
| Student > Master | 9 | 10% |
| Student > Bachelor | 7 | 8% |
| Student > Postgraduate | 5 | 6% |
| Other | 10 | 11% |
| Unknown | 19 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 39 | 44% |
| Biochemistry, Genetics and Molecular Biology | 25 | 28% |
| Unspecified | 1 | 1% |
| Psychology | 1 | 1% |
| Medicine and Dentistry | 1 | 1% |
| Other | 1 | 1% |
| Unknown | 21 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 48. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 January 2021.
All research outputs
#806,122
of 24,140,950 outputs
Outputs from Nature Communications
#13,472
of 51,291 outputs
Outputs of similar age
#14,836
of 303,856 outputs
Outputs of similar age from Nature Communications
#243
of 822 outputs
Altmetric has tracked 24,140,950 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 51,291 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.3. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 303,856 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 822 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.