| Title |
Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells
|
|---|---|
| Published in |
Archives of Dermatological Research, October 2010
|
| DOI | 10.1007/s00403-010-1088-6 |
| Pubmed ID | |
| Authors |
Gennady Rosenblat, Shai Meretski, Joseph Segal, Mark Tarshis, Avi Schroeder, Alexandra Zanin-Zhorov, Gilead Lion, Arieh Ingber, Malka Hochberg |
| Abstract |
Exposing skin to ultraviolet (UV) radiation contributes to photoaging and to the development of skin cancer by DNA lesions and triggering inflammatory and other harmful cellular cascades. The present study tested the ability of unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, to reduce UVB-induced damage and inflammation in skin. Introducing PFA to keratinocytes prior to their exposure to UVB exerted a protective effect, increasing cell viability, decreasing the secretion of IL-6 and PGE(2), and enhancing DNA repair. In human skin explants, treating with PFA reduced significantly UV-induced cellular damage. These results support the idea that PFA can play an important role as a photo-protective agent in UV-induced skin damage. |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| South Africa | 1 | <1% |
| Unknown | 100 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 24 | 24% |
| Researcher | 15 | 15% |
| Student > Ph. D. Student | 13 | 13% |
| Student > Bachelor | 9 | 9% |
| Student > Doctoral Student | 6 | 6% |
| Other | 18 | 18% |
| Unknown | 16 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 31 | 31% |
| Chemistry | 14 | 14% |
| Biochemistry, Genetics and Molecular Biology | 9 | 9% |
| Medicine and Dentistry | 8 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
| Other | 11 | 11% |
| Unknown | 22 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 56. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2024.
All research outputs
#748,327
of 25,120,346 outputs
Outputs from Archives of Dermatological Research
#17
of 1,447 outputs
Outputs of similar age
#2,048
of 104,949 outputs
Outputs of similar age from Archives of Dermatological Research
#2
of 11 outputs
Altmetric has tracked 25,120,346 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,447 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 104,949 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.