| Title |
α-Synuclein in the olfactory system of a mouse model of Parkinson’s disease: correlation with olfactory projections
|
|---|---|
| Published in |
Brain Structure and Function, September 2011
|
| DOI | 10.1007/s00429-011-0347-4 |
| Pubmed ID | |
| Authors |
Isabel Ubeda-Bañon, Daniel Saiz-Sanchez, Carlos de la Rosa-Prieto, Alino Martinez-Marcos |
| Abstract |
Olfactory deficits are an early feature of Parkinson's disease (PD). Neuropathologically, α-synucleinopathy (Lewy bodies and neurites) is observed earlier (stage 1) in the olfactory system than in the substantia nigra (stage 3), and this could underlies the early olfactory symptoms. In the present report, we analyzed the distribution of α-synuclein deposits in tertiary olfactory structures (anterior olfactory nucleus, olfactory tubercle, piriform cortex, posterolateral cortical amygdala and lateral entorhinal cortex) of homozygous transgenic mice (aged 2-8 months) overexpressing the human A53T variant of α-synuclein. To address the hypothesis of progressive α-synucleinopathy within the olfactory system, the distribution of α-synuclein was analyzed in conjunction with tracer injections into the main olfactory bulb. The time-course of α-synuclein expression revealed a significant increase in the piriform cortex at the age of 8 months compared to other brain structures. Tracing experiments revealed that olfactory projections are reduced in homozygous as compared to wild type animals. Double-labeling experiments show labeled axonal collaterals of mitral cells entering layer II of the piriform cortex in close proximity to α-synuclein-positive cells. To our knowledge, this is the first study addressing the progression of α-synuclein expression in a vulnerable neuronal pathway in PD. |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Spain | 1 | 2% |
| United States | 1 | 2% |
| Canada | 1 | 2% |
| Unknown | 54 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 21% |
| Researcher | 8 | 14% |
| Student > Master | 8 | 14% |
| Student > Bachelor | 7 | 12% |
| Student > Doctoral Student | 4 | 7% |
| Other | 13 | 22% |
| Unknown | 6 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 20 | 34% |
| Neuroscience | 15 | 26% |
| Medicine and Dentistry | 9 | 16% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Psychology | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 6 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2012.
All research outputs
#3,564,451
of 24,217,893 outputs
Outputs from Brain Structure and Function
#277
of 1,725 outputs
Outputs of similar age
#18,381
of 133,609 outputs
Outputs of similar age from Brain Structure and Function
#2
of 5 outputs
Altmetric has tracked 24,217,893 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,725 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 133,609 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.