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Localization of tumor necrosis factor in the canine testis, epididymis and spermatozoa

Overview of attention for article published in Theriogenology, January 2012
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Title
Localization of tumor necrosis factor in the canine testis, epididymis and spermatozoa
Published in
Theriogenology, January 2012
DOI 10.1016/j.theriogenology.2011.11.021
Pubmed ID
Authors

R. Payan-Carreira, I. Santana, M.A. Pires, B. Ström Holst, H. Rodriguez-Martinez

Abstract

Tumor necrosis factor (TNF), formerly known as Tumor necrosis factor alpha is now regarded as a natural component of the mammalian seminal plasma (SP). Although not completely clarified, its functions in the SP have been associated with paradoxal roles, such as sperm survival in the female genital tract, while at high levels negatively affect sperm survival and fertility potential. Recently, it has been discovered that canine inseminated spermatozoa display a strong immunoreaction for TNF when lining the female endometrium. As a continuation of this finding, the present work aimed at documenting TNF localization in the canine testes and epididymis and in freshly ejaculated spermatozoa (SPZ) through immunohisto- or cytochemistry. Immunoreaction for TNF was found in all samples used. In the dog testis, TNF immunoexpression was limited to the seminiferous tubules, where late round spermatids (SPD) showed weak intensity of immunostaining, while elongating and elongated SPD evidenced moderate and the residual bodies a strong intensity. In the epididymis, a gradual progressive increase of TNF immunolabelling was found throughout the epididymal regions, ranging from a weak intensity at the caput epididymis to a moderate intensity at the cauda. TNF immunolabelling was found in mature SPZ during the epididymal transit and also in freshly ejaculated SPZ, which showed a strong midpiece immunolabelling. Data presented here provide important information on expression of TNF in spermatozoa, which is acquired by the SPZ during their formation at the testis. It further provides the basis for subsequent studies on the physiological importance of cytokines in sperm function.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 6 23%
Student > Ph. D. Student 4 15%
Student > Master 3 12%
Researcher 3 12%
Professor 3 12%
Other 3 12%
Unknown 4 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 38%
Veterinary Science and Veterinary Medicine 5 19%
Pharmacology, Toxicology and Pharmaceutical Science 2 8%
Medicine and Dentistry 2 8%
Biochemistry, Genetics and Molecular Biology 1 4%
Other 2 8%
Unknown 4 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2012.
All research outputs
#22,759,452
of 25,373,627 outputs
Outputs from Theriogenology
#2,485
of 3,238 outputs
Outputs of similar age
#227,137
of 248,796 outputs
Outputs of similar age from Theriogenology
#16
of 22 outputs
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