| Title |
The immune system in the aging human
|
|---|---|
| Published in |
Immunologic Research, April 2012
|
| DOI | 10.1007/s12026-012-8289-3 |
| Pubmed ID | |
| Authors |
Paulina Dominika Rymkiewicz, Yi Xiong Heng, Anusha Vasudev, Anis Larbi |
| Abstract |
With the improvement of medical care and hygienic conditions, there has been a tremendous increment in human lifespan. However, many of the elderly (>65 years) display chronic illnesses, and a majority requires frequent and longer hospitalization. The robustness of the immune system to eliminate or control infections is often eroded with advancing age. Nevertheless, some elderly individuals do cope better than others. The origin of these inter-individual differences may come from genetic, lifestyle conditions (nutrition, socio-economic parameters), as well as the type, number and recurrence of pathogens encountered during life. The theory we are supporting is that chronic infections, through life, will induce profound changes in the immune system probably due to unbalanced inflammatory profiles. Persistent viruses such a cytomegalovirus are not eliminated and are a driven force to immune exhaustion. Because of their age, elderly individuals may have seen more of these chronic stimulators and have experienced more reactivation episodes ultimately leading to shrinkage of their repertoire and overall immune robustness. This review integrates updates on immunity with advancing age and its impact on associated clinical conditions. |
Mendeley readers
The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 5% |
| Netherlands | 1 | 2% |
| Denmark | 1 | 2% |
| France | 1 | 2% |
| Unknown | 59 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 20% |
| Student > Master | 13 | 20% |
| Student > Ph. D. Student | 12 | 18% |
| Student > Bachelor | 6 | 9% |
| Student > Doctoral Student | 5 | 8% |
| Other | 13 | 20% |
| Unknown | 3 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 31% |
| Agricultural and Biological Sciences | 13 | 20% |
| Biochemistry, Genetics and Molecular Biology | 7 | 11% |
| Immunology and Microbiology | 7 | 11% |
| Psychology | 4 | 6% |
| Other | 10 | 15% |
| Unknown | 4 | 6% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2012.
All research outputs
#3,571,629
of 22,664,267 outputs
Outputs from Immunologic Research
#115
of 904 outputs
Outputs of similar age
#23,724
of 161,215 outputs
Outputs of similar age from Immunologic Research
#8
of 30 outputs
Altmetric has tracked 22,664,267 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 904 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.9. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 161,215 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.