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Exploring the role of copy number variants in human adaptation

Overview of attention for article published in Trends in Genetics, April 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

news
2 news outlets
twitter
4 X users

Citations

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112 Dimensions

Readers on

mendeley
223 Mendeley
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3 CiteULike
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Title
Exploring the role of copy number variants in human adaptation
Published in
Trends in Genetics, April 2012
DOI 10.1016/j.tig.2012.03.002
Pubmed ID
Authors

Rebecca C. Iskow, Omer Gokcumen, Charles Lee

Abstract

Over the past decade, the ubiquity of copy number variants (CNVs, the gain or loss of genomic material) in the genomes of healthy humans has become apparent. Although some of these variants are associated with disorders, a handful of studies documented an adaptive advantage conferred by CNVs. In this review, we propose that CNVs are substrates for human evolution and adaptation. We discuss the possible mechanisms and evolutionary processes in which CNVs are selected, outline the current challenges in identifying these loci, and highlight that copy number variable regions allow for the creation of novel genes that may diversify the repertoire of such genes in response to rapidly changing environments. We expect that many more adaptive CNVs will be discovered in the coming years, and we believe that these new findings will contribute to our understanding of human-specific phenotypes.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 223 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 3%
United Kingdom 3 1%
Canada 3 1%
Australia 2 <1%
Korea, Republic of 1 <1%
Italy 1 <1%
Brazil 1 <1%
Chile 1 <1%
Netherlands 1 <1%
Other 1 <1%
Unknown 203 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 66 30%
Researcher 44 20%
Student > Master 20 9%
Student > Bachelor 16 7%
Professor 14 6%
Other 39 17%
Unknown 24 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 114 51%
Biochemistry, Genetics and Molecular Biology 47 21%
Medicine and Dentistry 7 3%
Social Sciences 6 3%
Computer Science 5 2%
Other 12 5%
Unknown 32 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2019.
All research outputs
#1,950,994
of 25,374,647 outputs
Outputs from Trends in Genetics
#300
of 2,382 outputs
Outputs of similar age
#11,111
of 173,563 outputs
Outputs of similar age from Trends in Genetics
#3
of 18 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,382 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.5. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 173,563 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.