| Title |
How to halve ploidy: lessons from budding yeast meiosis
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, April 2012
|
| DOI | 10.1007/s00018-012-0974-9 |
| Pubmed ID | |
| Authors |
Gary William Kerr, Sourav Sarkar, Prakash Arumugam |
| Abstract |
Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells. Meiotic cells halve their ploidy by undergoing two rounds of nuclear division (meiosis I and II) after a single round of DNA replication. Research in Saccharomyces cerevisiae (budding yeast) has shown that four major deviations from the mitotic cell cycle during meiosis are essential for halving ploidy. The deviations are (1) formation of a link between homologous chromosomes by crossover, (2) monopolar attachment of sister kinetochores during meiosis I, (3) protection of centromeric cohesion during meiosis I, and (4) suppression of DNA replication following exit from meiosis I. In this review we present the current understanding of the above four processes in budding yeast and examine the possible conservation of molecular mechanisms from yeast to humans. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 33% |
| United States | 1 | 11% |
| Canada | 1 | 11% |
| Italy | 1 | 11% |
| Unknown | 3 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 67% |
| Scientists | 2 | 22% |
| Unknown | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| France | 1 | 2% |
| Unknown | 63 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 23% |
| Student > Ph. D. Student | 14 | 22% |
| Student > Master | 9 | 14% |
| Student > Bachelor | 8 | 12% |
| Professor > Associate Professor | 4 | 6% |
| Other | 9 | 14% |
| Unknown | 6 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 36 | 55% |
| Biochemistry, Genetics and Molecular Biology | 17 | 26% |
| Philosophy | 1 | 2% |
| Computer Science | 1 | 2% |
| Immunology and Microbiology | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 6 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2015.
All research outputs
#6,022,520
of 24,707,218 outputs
Outputs from Cellular and Molecular Life Sciences
#1,556
of 5,627 outputs
Outputs of similar age
#38,727
of 165,645 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#18
of 46 outputs
Altmetric has tracked 24,707,218 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,627 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 72% of its peers.
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We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.