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Antibody-Drug Conjugates

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Cover of 'Antibody-Drug Conjugates'

Table of Contents

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    Book Overview
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    Chapter 1 An Overview of the Current ADC Discovery Landscape
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    Chapter 2 Pushing the Envelope: Advancement of ADCs Outside of Oncology
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    Chapter 3 Conjugations to Endogenous Cysteine Residues
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    Chapter 4 Site-Specific Conjugation to Cys-Engineered THIOMAB™ Antibodies
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    Chapter 5 Transglutaminase-Mediated Conjugations
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    Chapter 6 Click Chemistry Conjugations
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    Chapter 7 Utilizing Solid-Phase to Enable High-Throughput, Site-Specific Conjugation and Dual-Labeled Antibody and Fab Conjugates
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    Chapter 8 Bridged Cysteine Conjugations
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    Chapter 9 Antibody Conjugations via Glycosyl Remodeling
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    Chapter 10 ADC Analysis by Hydrophobic Interaction Chromatography
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    Chapter 11 Two-Dimensional Liquid Chromatography Coupled to High-Resolution Mass Spectrometry for the Analysis of ADCs
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    Chapter 12 Drug Loading and Distribution of ADCs After Reduction or IdeS Digestion and Reduction
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    Chapter 13 Analysis of ADCs by Native Mass Spectrometry
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    Chapter 14 High-Resolution Characterization of ADCs by Orbitrap LCMS
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    Chapter 15 Conjugation Site Analysis by MS/MS Protein Sequencing
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    Chapter 16 Conjugation Site Analysis of Lysine-Conjugated ADCs
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    Chapter 17 Characterization of ADCs by Capillary Electrophoresis
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    Chapter 18 Characterization of the Primary Structure of Cysteine-Linked Antibody-Drug Conjugates Using Capillary Electrophoresis with Mass Spectrometry
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    Chapter 19 Purification of ADCs by Hydrophobic Interaction Chromatography
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    Chapter 20 Detection and Removal of Small Molecule and Endotoxin Contaminants in ADC Preparations
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    Chapter 21 Physical Stability Studies of Antibody-Drug Conjugates (ADCs) Under Stressed Conditions
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    Chapter 22 Biophysical Methods for Characterization of Antibody-Drug Conjugates
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    Chapter 23 Determination of ADC Cytotoxicity in Immortalized Human Cell Lines
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    Chapter 24 LC/MS Methods for Studying Lysosomal ADC Catabolism
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    Chapter 25 Assessing ADC Plasma Stability by LC-MS Methods
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    Chapter 26 Determination of ADC Concentration by Ligand-Binding Assays
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Title
Antibody-Drug Conjugates
Published by
Springer US, January 2020
DOI 10.1007/978-1-4939-9929-3
ISBNs
978-1-4939-9928-6, 978-1-4939-9929-3
Editors

L. Nathan Tumey

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 7%
Student > Doctoral Student 1 3%
Unknown 26 90%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 7%
Chemistry 1 3%
Unknown 26 90%