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Balancing selection on immunity genes: review of the current literature and new analysis in Drosophila melanogaster

Overview of attention for article published in Zoology, March 2016
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  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

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Title
Balancing selection on immunity genes: review of the current literature and new analysis in Drosophila melanogaster
Published in
Zoology, March 2016
DOI 10.1016/j.zool.2016.03.004
Pubmed ID
Authors

Myriam Croze, Daniel Živković, Wolfgang Stephan, Stephan Hutter

Abstract

Balancing selection has been widely assumed to be an important evolutionary force, yet even today little is known about its abundance and its impact on the patterns of genetic diversity. Several studies have shown examples of balancing selection in humans, plants or parasites, and many genes under balancing selection are involved in immunity. It has been proposed that host-parasite coevolution is one of the main forces driving immune genes to evolve under balancing selection. In this paper, we review the literature on balancing selection on immunity genes in several organisms, including Drosophila. Furthermore, we performed a genome scan for balancing selection in an African population of Drosophila melanogaster using coalescent simulations of a demographic model with and without selection. We find very few genes under balancing selection and only one novel candidate gene related to immunity. Finally, we discuss the possible causes of the low number of genes under balancing selection.

X Demographics

X Demographics

The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Unknown 73 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 28%
Researcher 13 18%
Student > Bachelor 10 14%
Student > Master 10 14%
Student > Postgraduate 4 5%
Other 5 7%
Unknown 11 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 38 51%
Biochemistry, Genetics and Molecular Biology 16 22%
Environmental Science 3 4%
Immunology and Microbiology 2 3%
Mathematics 1 1%
Other 3 4%
Unknown 11 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2016.
All research outputs
#6,496,106
of 25,374,647 outputs
Outputs from Zoology
#146
of 536 outputs
Outputs of similar age
#89,639
of 329,938 outputs
Outputs of similar age from Zoology
#8
of 19 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 536 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,938 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.