| Title |
Non-essential contribution of LRRC8A to volume regulation
|
|---|---|
| Published in |
Pflügers Archiv - European Journal of Physiology, February 2016
|
| DOI | 10.1007/s00424-016-1789-6 |
| Pubmed ID | |
| Authors |
Lalida Sirianant, Podchanart Wanitchakool, Jiraporn Ousingsawat, Roberta Benedetto, Anna Zormpa, Ines Cabrita, Rainer Schreiber, Karl Kunzelmann |
| Abstract |
Volume regulation is an essential property of any living cell and needs to be tightly controlled. While different types of K(+) channels have been found to participate in the regulation of cell volume, the newly identified volume-regulated anion channel (VRAC) LRRC8 has been claimed to be essential for volume regulation. In unbiased genome-wide small interfering RNA (siRNA) screens, two independent studies identified LRRC8A/Swell1 as an essential component of VRAC, thus being indispensable for cellular volume regulation. We reanalyzed the role of LRRC8A for VRAC and regulatory volume decrease (RVD) in several cell types and under various conditions. While the role of LRRC8A for VRAC and its contribution to RVD is confirmed, we find that it is not essential for swelling-activated anion currents or cellular volume regulation, or apoptotic cell shrinkage. The contribution of LRRC8A is variable and largely depending on the cell type. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Canada | 1 | 2% |
| Unknown | 50 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 27% |
| Student > Ph. D. Student | 12 | 23% |
| Student > Master | 6 | 12% |
| Other | 3 | 6% |
| Professor > Associate Professor | 2 | 4% |
| Other | 5 | 10% |
| Unknown | 10 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 16 | 31% |
| Agricultural and Biological Sciences | 11 | 21% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 8% |
| Neuroscience | 3 | 6% |
| Medicine and Dentistry | 3 | 6% |
| Other | 3 | 6% |
| Unknown | 12 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2016.
All research outputs
#19,221,261
of 23,815,455 outputs
Outputs from Pflügers Archiv - European Journal of Physiology
#1,557
of 1,973 outputs
Outputs of similar age
#295,699
of 404,861 outputs
Outputs of similar age from Pflügers Archiv - European Journal of Physiology
#14
of 26 outputs
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