| Title |
Genistein cooperates with the histone deacetylase inhibitor vorinostat to induce cell death in prostate cancer cells
|
|---|---|
| Published in |
BMC Cancer, April 2012
|
| DOI | 10.1186/1471-2407-12-145 |
| Pubmed ID | |
| Authors |
Cornel J Phillip, Christopher K Giardina, Birdal Bilir, David J Cutler, Yu-Heng Lai, Omer Kucuk, Carlos S Moreno |
| Abstract |
Among American men, prostate cancer is the most common, non-cutaneous malignancy that accounted for an estimated 241,000 new cases and 34,000 deaths in 2011. Previous studies have suggested that Wnt pathway inhibitory genes are silenced by CpG hypermethylation, and other studies have suggested that genistein can demethylate hypermethylated DNA. Genistein is a soy isoflavone with diverse effects on cellular proliferation, survival, and gene expression that suggest it could be a potential therapeutic agent for prostate cancer. We undertook the present study to investigate the effects of genistein on the epigenome of prostate cancer cells and to discover novel combination approaches of other compounds with genistein that might be of translational utility. Here, we have investigated the effects of genistein on several prostate cancer cell lines, including the ARCaP-E/ARCaP-M model of the epithelial to mesenchymal transition (EMT), to analyze effects on their epigenetic state. In addition, we investigated the effects of combined treatment of genistein with the histone deacetylase inhibitor vorinostat on survival in prostate cancer cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| United States | 1 | 2% |
| Unknown | 39 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 20% |
| Student > Master | 6 | 15% |
| Student > Bachelor | 6 | 15% |
| Researcher | 5 | 12% |
| Student > Doctoral Student | 3 | 7% |
| Other | 8 | 20% |
| Unknown | 5 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 20% |
| Biochemistry, Genetics and Molecular Biology | 7 | 17% |
| Agricultural and Biological Sciences | 7 | 17% |
| Mathematics | 2 | 5% |
| Psychology | 2 | 5% |
| Other | 6 | 15% |
| Unknown | 9 | 22% |